Evidence map›Paper›PMID 33907368›Full record

ArticleMolecular vision2021

Enzymatic vitreolysis using reengineered

Mithun Santra, Maryada Sharma, Deeksha Katoch, Sahil Jain, Uma Nahar Saikia, Mangat R Dogra, Manni Luthra-Guptasarma

Open access · greenAbstract readValidation Study
PubMed Full text at PMC
In one paragraph

Article in Molecular vision, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Mithun SantraDepartment of Immunopathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Maryada SharmaDepartment of Immunopathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Deeksha KatochDepartment of Ophthalmology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Sahil JainDepartment of Ophthalmology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Uma Nahar SaikiaDepartment of Histopathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Mangat R DograDepartment of Ophthalmology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Manni Luthra-GuptasarmaDepartment of Immunopathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Post Graduate Institute of Medical Education and Research · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: Collagen is a key player contributing to vitreoelasticity and vitreoretinal adhesions. Molecular reorganization causes spontaneous weakening of these adhesions with age, resulting in the separation of the posterior hyaloid membrane (PHM) from the retina in what is called complete posterior vitreous detachment (PVD). Incomplete separation of the posterior hyaloid or tight adherence or both can lead to retinal detachment, vitreomacular traction syndrome, or epiretinal membrane formation, which requires surgical intervention. Pharmacological vitrectomy has the potential of avoiding surgical vitrectomy; it is also useful as an adjunct during retinal surgery to induce PVD. Previously studied enzymatic reagents, such as collagenase derived from Methods: VMA and iHA-VMA were expressed in Results: The activity of iHA-VMA and VMA was comparable and 65-fold lower than that of Conclusions: iHA-VMA displays targeted action confined to the vitreous and shows potential for safe pharmacologic vitreolysis.

Indexed as

AnimalsCell SurvivalCollagenasesElectrophoresis, Polyacrylamide GelFlow CytometryGoatsHyaluronic AcidIntravitreal InjectionsMicroscopy, Electron, ScanningOphthalmoscopyRabbitsRecombinant Fusion ProteinsRetinaVibrio mimicusVitrectomyVitreous BodyCollagenasesHyaluronic AcidRecombinant Fusion Proteins

Identifiers

PMID33907368
PMCPMC8056467
OpenAlexW3157180586

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.