ArticleScientific reports2021
Multiple cytochrome P450 genes: conferring high levels of permethrin resistance in mosquitoes, Culex quinquefasciatus.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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27 citing papers in PubMed, 48 citations in OpenAlex.
- Comparative genomics reveal signatures of ecological specialization in the striped ambrosia beetle Trypodendron lineatum.BMC genomics · 2026Article
- Soft Selective Sweeps Predominate in the Yellow Fever Mosquito Aedes aegypti.Molecular biology and evolution · 2026Article
- Biochemical, molecular, and in silico insights into the effects of cyphenothrin on Culex quinquefasciatus mosquitoes.Parasites & vectors · 2026Article
- Molecular Characterization of Cytochrome P450 Genes (CYP9M10 and CYP4H34) in Insecticide-Resistant and Susceptible Strains ofJournal of arthropod-borne diseases · 2026Article
- NADPH-cytochrome P450 reductase involved in the multi-resistance ofFrontiers in physiology · 2026Article
- Expression of cytochrome P450 monooxygenase genes in pyrethroid-resistant Aedes albopictus.Scientific reports · 2025Article
- The contribution of transposable element insertions to genetic diversity inbioRxiv : the preprint server for biology · 2025Article
- Global distribution and impact of knockdown resistance mutations in Aedes aegypti on pyrethroid resistance.Parasites & vectors · 2025Review
- Signatures of soft selective sweeps predominate in the yellow fever mosquitobioRxiv : the preprint server for biology · 2025Article
- Article
- Overexpression of multiple cytochrome P450 genes with and without knockdown resistance mutations confers high resistance to deltamethrin in Culex quinquefasciatus.Infectious diseases of poverty · 2025Article
- The P450-Monooxygenase Activity and CYP6D1 Expression in the Chlorfenapyr-Resistant Strain ofInsects · 2024Article
- Lack of fitness costs associated with resistance to permethrin in Musca domestica.Scientific reports · 2024Article
- Overexpression of cytochrome P450 and esterase genes involved in permethrin resistance in larvae and adults of Culex quinquefasciatus.Parasitology research · 2023Article
- Larvicidal and Adulticidal Activity of Essential Oils from Four Cuban Plants against Three Mosquito Vector Species.Plants (Basel, Switzerland) · 2023Article
- Quantitative proteomics analysis of permethrin and temephos-resistant Ae. aegypti revealed diverse differentially expressed proteins associated with insecticide resistance from Penang Island, Malaysia.PLoS neglected tropical diseases · 2023Article
- Article
- Transcriptome Analysis of Response to Zika Virus Infection in TwoInternational journal of molecular sciences · 2023Article
- Multiple-P450 Gene Co-Up-Regulation in the Development of Permethrin Resistance in the House Fly,International journal of molecular sciences · 2023Article
- Article
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Insecticides, especially pyrethroids, are the most important in the insect pest control and preventing insect vector-borne human diseases. However, insect pests, including mosquitoes, have developed resistance in the insecticides that used against them. Cytochrome P450s are associated with insecticide resistance through overexpression and detoxification mechanisms in insect species. In this study, we utilized a powerful tool, the RNAi technique, to determine the roles of key P450 genes overexpressed in permethrin resistant mosquitoes that confer insecticide resistance to unravel the molecular basis of resistance mechanisms in the mosquito Culex quinquefasciatus. The results showed that knockdown of 8 key P450 genes using RNAi techniques significantly decreased resistance to permethrin in resistant mosquitoes. In silico modeling and docking analysis further revealed the potential metabolic function of overexpressed P450 genes in the development of insecticide resistance in mosquitoes. These findings not only highlighted the functional importance of these P450 genes in insecticide resistance, but also revealed that overexpression of multiple P450 genes was responsible for the high levels of insecticide resistance in a mosquito population of Culex quinquefasciatus.
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