Evidence map›Paper›PMID 33907231›Full record

ArticleScientific reports2021

Hedgehog interacting protein (HHIP) represses airway remodeling and metabolic reprogramming in COPD-derived airway smooth muscle cells.

Yan Li, Li Zhang, Francesca Polverino, Feng Guo, Yuan Hao, Taotao Lao, Shuang Xu, Lijia Li, Betty Pham, Caroline A Owen and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 35 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Residential Green and Blue Space, the Natural Environment, Genetic Susceptibility, and Incident COPD.International journal of chronic obstructive pulmonary disease · 2026
    Article
  6. Dissecting Hhip1 FunctionActa histochemica et cytochemica · 2025
    Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Review
  12. Review
  13. Unraveling Dysanapsis: Genetic Insights into Airway Lung Mismatch and COPD.American journal of respiratory and critical care medicine · 2024
    Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Activation of CD8American journal of respiratory and critical care medicine · 2023
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Yan LiSchool of Medicine, Cheeloo College of Medicine, Shandong University, Jinan, 250012, Shandong Province, China. yanli.sdu@gmail.com.
Li ZhangChanning Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA.
Francesca PolverinoAsthma and Airway Disease Research Center, University of Arizona, Medicine, Tucson, AZ, 85724, USA.
Feng GuoChanning Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA.
Yuan HaoChanning Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA.
Taotao LaoCenter for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston, MA, 02129, USA.
Shuang XuChanning Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA.
Lijia LiChanning Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA.
Betty PhamChanning Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA.
Caroline A OwenDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA.
Xiaobo ZhouChanning Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA. xiaobo.zhou@channing.harvard.edu.
Harvard University · USBrigham and Women's Hospital · USMassachusetts General Hospital · USUniversity of Arizona · US

Funding

Metabolic Control of Stemness in lung epithelial progenitors by FAM13AR01HL127200 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI ZHOU, ANNY XIAOBO · 2015 to 2024
$4.9M
Integrative Characterization on the function of COPD GWAS gene, HHIPR01HL148667 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI WEI, WENYI, ZHOU, ANNY XIAOBO · 2020 to 2023
$2.6M
NHLBI NIH HHS R01 HL127200NHLBI NIH HHS R01 HL148667NIH HHS R01HL127200
6 · The paper itself

Abstract

Although HHIP locus has been consistently associated with the susceptibility to COPD including airway remodeling and emphysema in genome-wide association studies, the molecular mechanism underlying this genetic association remains incompletely understood. By utilizing Hhip

Indexed as

AdultAirway RemodelingAnimalsCarrier ProteinsCell ProliferationCigarette SmokingFemaleGlycolysisHaploinsufficiencyHumansLungMaleMembrane GlycoproteinsMembrane ProteinsMiceMice, Inbred C57BLCarrier ProteinsHHIP protein, humanHhip protein, mouseMembrane GlycoproteinsMembrane ProteinsThyroid Hormone-Binding ProteinsThyroid Hormones

Identifiers

PMID33907231
PMCPMC8079715
OpenAlexW3159624821

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.