ArticleProceedings of the National Academy of Sciences of the United States of America2021
Improved bounds on entropy production in living systems.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 111 citations in OpenAlex.
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- Incoherent feedforward loop dominates the robustness and tunability of necroptosis biphasic, emergent, and coexistent dynamics.Fundamental research · 2026Article
- Stochastic motility energetics reveals cooperative bacterial swarming in optical tweezers.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Mapping Local Dissipation and Entropy Production in Complex and Active Fluids.The journal of physical chemistry letters · 2025Article
- 'Intelligent' proteins.Cellular and molecular life sciences : CMLS · 2025Review
- Auditory cellular cooperativity probed via spontaneous otoacoustic emissions.Biophysical journal · 2025Article
- Single gene analysis in yeast suggests nonequilibrium regulatory dynamics for transcription.Nature communications · 2024Article
- Decreasing Intracellular Entropy by Increasing Mitochondrial Efficiency and Reducing ROS Formation-The Effect on the Ageing Process and Age-Related Damage.International journal of molecular sciences · 2024Review
- Density physics-informed neural networks reveal sources of cell heterogeneity in signal transduction.Patterns (New York, N.Y.) · 2024Article
- Functional hierarchies in brain dynamics characterized by signal reversibility in ferret cortex.PLoS computational biology · 2024Article
- Article
- Inferring entropy production rate from partially observed Langevin dynamics under coarse-graining.Physical chemistry chemical physics : PCCP · 2022Article
- Decomposing the Local Arrow of Time in Interacting Systems.Physical review letters · 2022Article
- Emergence of local irreversibility in complex interacting systems.Physical review. E · 2022Article
- Bayesian mechanics for stationary processes.Proceedings. Mathematical, physical, and engineering sciences · 2021Article
- Algorithmic Approaches for Assessing Irreversibility in Time Series: Review and Comparison.Entropy (Basel, Switzerland) · 2021Article
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2 authors at 1 institution in 1 country.
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Abstract
Living systems maintain or increase local order by working against the second law of thermodynamics. Thermodynamic consistency is restored as they consume free energy, thereby increasing the net entropy of their environment. Recently introduced estimators for the entropy production rate have provided major insights into the efficiency of important cellular processes. In experiments, however, many degrees of freedom typically remain hidden to the observer, and, in these cases, existing methods are not optimal. Here, by reformulating the problem within an optimization framework, we are able to infer improved bounds on the rate of entropy production from partial measurements of biological systems. Our approach yields provably optimal estimates given certain measurable transition statistics. In contrast to prevailing methods, the improved estimator reveals nonzero entropy production rates even when nonequilibrium processes appear time symmetric and therefore may pretend to obey detailed balance. We demonstrate the broad applicability of this framework by providing improved bounds on the energy consumption rates in a diverse range of biological systems including bacterial flagella motors, growing microtubules, and calcium oscillations within human embryonic kidney cells.
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