Evidence map›Paper›PMID 33906945›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

Anaerobic gut fungi are an untapped reservoir of natural products.

Candice L Swift, Katherine B Louie, Benjamin P Bowen, Heather M Olson, Samuel O Purvine, Asaf Salamov, Stephen J Mondo, Kevin V Solomon, Aaron T Wright, Trent R Northen and 3 more

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
7.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 68 citations in OpenAlex.

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  12. Exploitation of Biodiversity in Bioeconomy: Examples, Opportunities, and Challenges.Advances in biochemical engineering/biotechnology · 2025
    Review
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  15. Effects of Spent Substrate of Oyster Mushroom (Animals : an open access journal from MDPI · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 1 country.

Candice L SwiftDepartment of Chemical Engineering, University of California, Santa Barbara, CA 93106.
Katherine B LouieDepartment of Energy Joint Genome Institute, Lawrence Berkeley National Laboratory, Berkeley, CA 94720.
Benjamin P BowenDepartment of Energy Joint Genome Institute, Lawrence Berkeley National Laboratory, Berkeley, CA 94720.
Heather M OlsonEarth and Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99352.ORCID 0000-0002-4501-9587
Samuel O PurvineEarth and Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99352.ORCID 0000-0002-2257-2400
Asaf SalamovDepartment of Energy Joint Genome Institute, Lawrence Berkeley National Laboratory, Berkeley, CA 94720.ORCID 0000-0002-3349-8138
Stephen J MondoDepartment of Energy Joint Genome Institute, Lawrence Berkeley National Laboratory, Berkeley, CA 94720.
Kevin V SolomonDepartment of Agricultural and Biological Engineering, Purdue University, West Lafayette, IN 47907.ORCID 0000-0003-2904-9118
Aaron T WrightEarth and Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99352.ORCID 0000-0002-3172-5253
Trent R NorthenDepartment of Energy Joint Genome Institute, Lawrence Berkeley National Laboratory, Berkeley, CA 94720.
Igor V GrigorievDepartment of Energy Joint Genome Institute, Lawrence Berkeley National Laboratory, Berkeley, CA 94720.ORCID 0000-0002-3136-8903
Nancy P KellerDepartment of Medical Microbiology and Immunology and Bacteriology, University of Wisconsin-Madison, Madison, WI 53706.ORCID 0000-0002-4386-9473
Michelle A O'MalleyDepartment of Chemical Engineering, University of California, Santa Barbara, CA 93106; momalley@ucsb.edu.ORCID 0000-0002-6065-8491
Lawrence Berkeley National Laboratory · USPacific Northwest National Laboratory · USUniversity of California, Santa Barbara · USPurdue University West Lafayette · USUniversity of Wisconsin–Madison · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Anaerobic fungi (class Neocallimastigomycetes) thrive as low-abundance members of the herbivore digestive tract. The genomes of anaerobic gut fungi are poorly characterized and have not been extensively mined for the biosynthetic enzymes of natural products such as antibiotics. Here, we investigate the potential of anaerobic gut fungi to synthesize natural products that could regulate membership within the gut microbiome. Complementary 'omics' approaches were combined to catalog the natural products of anaerobic gut fungi from four different representative species:

Indexed as

ProteomicsAnaerobiosisBiological ProductsBiomassChromatography, LiquidFungal ProteinsFungiGastrointestinal MicrobiomeLigninNeocallimastigalesNeocallimastixPiromycesTandem Mass SpectrometryBiological ProductsFungal ProteinsLigninanaerobesfunginatural productssecondary metabolismtranscriptomics

Identifiers

PMID33906945
PMCPMC8106346
OpenAlexW3157658372

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.