Evidence map›Paper›PMID 33906936›Full record

SynthesisJournal of neurology, neurosurgery, and psychiatry2021

Defining functional brain networks underlying obsessive-compulsive disorder (OCD) using treatment-induced neuroimaging changes: a systematic review of the literature.

Kelly R Bijanki, Yagna J Pathak, Ricardo A Najera, Eric A Storch, Wayne K Goodman, H Blair Simpson, Sameer A Sheth

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of neurology, neurosurgery, and psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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  20. Advances in Deep Brain Stimulation: From Mechanisms to Applications.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Kelly R Bijanki *Department of Neurosurgery, Baylor College of Medicine, Houston, Texas, USA.ORCID 0000-0003-1624-8767
Yagna J Pathak *Department of Neurological Surgery, Columbia University Medical Center, New York, New York, USA.
Ricardo A NajeraDepartment of Neurosurgery, Baylor College of Medicine, Houston, Texas, USA.
Eric A StorchMenninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, USA.
Wayne K GoodmanMenninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, USA.
H Blair SimpsonDepartment of Psychiatry, Columbia University Medical Center, New York, New York, USA.
Sameer A ShethDepartment of Neurosurgery, Baylor College of Medicine, Houston, Texas, USA Sameer.Sheth@bcm.edu.

Funding

Mapping and Modulating the Spatiotemporal dynamics of socio-affective processing.R01MH127006 · NIMH · BAYLOR COLLEGE OF MEDICINE · PI BIJANKI, KELLY ROWE · 2021 to 2025
$3.2M
The human amygdala in social processing: circuits, physiology, behavior, and neuromodulationK01MH116364 · NIMH · EMORY UNIVERSITY · PI BIJANKI, KELLY ROWE · 2018 to 2021
$650k
Novel Strategies for Mapping the Emotional Neural Circuitry Using Human Brain StimulationR21NS104953 · NINDS · EMORY UNIVERSITY · PI BIJANKI, KELLY ROWE, WILLIE, JON TIMOTHY · 2018 to 2019
$385k
NIMH NIH HHS K01 MH116364NIMH NIH HHS R01 MH127006NINDS NIH HHS R21 NS104953
6 · The paper itself

Abstract

Approximately 2%-3% of the population suffers from obsessive-compulsive disorder (OCD). Several brain regions have been implicated in the pathophysiology of OCD, but their various contributions remain unclear. We examined changes in structural and functional neuroimaging before and after a variety of therapeutic interventions as an index into identifying the underlying networks involved. We identified 64 studies from 1990 to 2020 comparing pretreatment and post-treatment imaging of patients with OCD, including metabolic and perfusion, neurochemical, structural, functional and connectivity-based modalities. Treatment class included pharmacotherapy, cognitive-behavioural therapy/exposure and response prevention, stereotactic lesions, deep brain stimulation and transcranial magnetic stimulation. Changes in several brain regions are consistent and correspond with treatment response despite the heterogeneity in treatments and neuroimaging modalities. Most notable are decreases in metabolism and perfusion of the caudate, anterior cingulate cortex, thalamus and regions of prefrontal cortex (PFC) including the orbitofrontal cortex (OFC), dorsolateral PFC (DLPFC), ventromedial PFC (VMPFC) and ventrolateral PFC (VLPFC). Modulating activity within regions of the cortico-striato-thalamo-cortical system may be a common therapeutic mechanism across treatments. We identify future needs and current knowledge gaps that can be mitigated by implementing integrative methods. Future studies should incorporate a systematic, analytical approach to testing objective correlates of treatment response to better understand neurophysiological mechanisms of dysfunction.

Indexed as

BrainDeep Brain StimulationHumansNerve NetNeuroimagingObsessive-Compulsive DisorderTranscranial Magnetic Stimulationbehavioural disorderbrain mappingfunctional imagingneurosurgerypetpsychiatry

Identifiers

PMID33906936
PMCPMC8223624

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.