Evidence map›Paper›PMID 33906924›Full record

ArticlemBio2021

Amoeba Predation of Cryptococcus neoformans Results in Pleiotropic Changes to Traits Associated with Virulence.

Man Shun Fu, Livia C Liporagi-Lopes, Samuel R Dos Santos, Jennifer L Tenor, John R Perfect, Christina A Cuomo, Arturo Casadevall

Open access · goldAbstract read
In one paragraph

Article in mBio, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 1 pooled it
6.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.

  1. The Implication of Horizontal Gene Transfer BetweenPathogens (Basel, Switzerland) · 2026
    Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Tracing the evolution and genomic dynamics of mating-type loci inbioRxiv : the preprint server for biology · 2025
    Article
  9. The emergence of neuroinvasiveFrontiers in cellular and infection microbiology · 2025
    Article
  10. Review
  11. Article
  12. Review
  13. Article
  14. Review
  15. Ergosterol Is Critical for Sporogenesis inJournal of fungi (Basel, Switzerland) · 2024
    Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Man Shun FuDepartment of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Livia C Liporagi-LopesDepartment of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Samuel R Dos SantosDepartment of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Jennifer L TenorDivision of Infectious Diseases, Department of Medicine and Department of Molecular Genetics and Microbiology, Duke University, Durham, North Carolina, USA.
John R PerfectDivision of Infectious Diseases, Department of Medicine and Department of Molecular Genetics and Microbiology, Duke University, Durham, North Carolina, USA.
Christina A CuomoInfectious Disease and Microbiome Program, Broad Institute, Cambridge, Massachusetts, USA.ORCID 0000-0002-5778-960X
Arturo CasadevallDepartment of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA acasade1@jhu.edu.ORCID 0000-0002-9402-9167
Johns Hopkins University · USDuke University · USBroad Institute · USUniversidade Federal do Rio de Janeiro · BR

Funding

Viral Genomics: evolution, spread, and host interactionsU19AI110818 · NIAID · BROAD INSTITUTE, INC. · PI SABETI, PARDIS CHRISTINE · 2014 to 2024
$66.5M
Synergy of Host Defense Mechanisms in the LungR01HL059842 · NHLBI · YESHIVA UNIVERSITY · PI CASADEVALL, ARTURO · 1997 to 2023
$7.4M
Evolution of Cryptococcus neoformans Strains from Patients with HIV/AIDSR01AI093257 · NIAID · DUKE UNIVERSITY · PI PERFECT, JOHN R. · 2011 to 2022
$3.8M
NHLBI NIH HHS R01 HL059842NIAID NIH HHS R01 AI093257NIAID NIH HHS U19 AI110818
6 · The paper itself

Abstract

Amoeboid predators, such as amoebae, are proposed to select for survival traits in soil microbes such as

Indexed as

PhagocytosisAcanthamoeba castellaniiAnimalsCryptococcosisCryptococcus neoformansCytokinesFemaleHumansLarvaMacrophagesMiceMice, Inbred C57BLMothsPhagocytesPhenotypeVirulenceCytokinesAcanthamoeba castellaniiamoebaCryptococcus neoformansevolutionhost-pathogen interactionsmacrophagesopportunistic fungi

Identifiers

PMID33906924
PMCPMC8092252
OpenAlexW3157850833

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.