Evidence map›Paper›PMID 33906900›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2021

Mutually Repulsive EphA7-EfnA5 Organize Region-to-Region Corticopontine Projection by Inhibiting Collateral Extension.

Tokuichi Iguchi, Yuichiro Oka, Misato Yasumura, Minoru Omi, Kazuki Kuroda, Hideshi Yagi, Min-Jue Xie, Manabu Taniguchi, Martin Bastmeyer, Makoto Sato

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Tokuichi IguchiDepartment of Anatomy and Neuroscience, Graduate School of Medicine, Osaka University, Osaka 565-0871, Japan.ORCID https://orcid.org/0000-0003-4025-8770
Yuichiro OkaDepartment of Anatomy and Neuroscience, Graduate School of Medicine, Osaka University, Osaka 565-0871, Japan.
Misato YasumuraDepartment of Anatomy and Neuroscience, Graduate School of Medicine, Osaka University, Osaka 565-0871, Japan.
Minoru OmiDivision of Cell Biology and Neuroscience, Department of Morphological and Physiological Sciences, Faculty of Medical Sciences, University of Fukui, Fukui 910-1193, Japan.
Kazuki KurodaDivision of Cell Biology and Neuroscience, Department of Morphological and Physiological Sciences, Faculty of Medical Sciences, University of Fukui, Fukui 910-1193, Japan.
Hideshi YagiDivision of Cell Biology and Neuroscience, Department of Morphological and Physiological Sciences, Faculty of Medical Sciences, University of Fukui, Fukui 910-1193, Japan.
Min-Jue XieDivision of Cell Biology and Neuroscience, Department of Morphological and Physiological Sciences, Faculty of Medical Sciences, University of Fukui, Fukui 910-1193, Japan.
Manabu TaniguchiDepartment of Anatomy and Neuroscience, Graduate School of Medicine, Osaka University, Osaka 565-0871, Japan.
Martin BastmeyerDepartment of Cell and Neurobiology, Zoological Institute, Karlsruhe Institute of Technology (KIT), 76131 Karlsruhe, Germany.
Makoto SatoDepartment of Anatomy and Neuroscience, Graduate School of Medicine, Osaka University, Osaka 565-0871, Japan makosato@anat2.med.osaka-u.ac.jp.ORCID https://orcid.org/0000-0002-6805-8351
University of Fukui · JPKanazawa University · JPThe University of Osaka · JPKarlsruhe Institute of Technology · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Coordination of skilled movements and motor planning relies on the formation of regionally restricted brain circuits that connect cortex with subcortical areas during embryonic development. Layer 5 neurons that are distributed across most cortical areas innervate the pontine nuclei (basilar pons) by protrusion and extension of collateral branches interstitially along their corticospinal extending axons. Pons-derived chemotropic cues are known to attract extending axons, but molecules that regulate collateral extension to create regionally segregated targeting patterns have not been identified. Here, we discovered that

Indexed as

AnimalsAxon GuidanceEphrin-A5FemaleMaleMiceMice, Inbred C57BLNeocortexNeural PathwaysPonsReceptor, EphA7Ephrin-A5Receptor, EphA7collateralcortexcorticospinal tractneuronal circuitpontine nucleus

Identifiers

PMID33906900
PMCPMC8260171
OpenAlexW3157655464

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.