Evidence map›Paper›PMID 33906698›Full record

SynthesisAIDS research and therapy2021

The prevalence of depression among adolescent with HIV/AIDS: a systematic review and meta-analysis.

Getinet Ayano, Sileshi Demelash, Mebratu Abraha, Light Tsegay

Registry-linked trialOpen access · goldAbstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in AIDS research and therapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07221201 (Reducing the Intersecting Stigmas of HIV, Violence Victimization, and Mental Health), which is not on this map. Cited by 40 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07221201 nacompletednot on this mapstarted 2025, after this paper: background citation

Reducing the Intersecting Stigmas of HIV, Violence Victimization, and Mental Health: a Randomized Controlled Pilot Integrating Project YES! Youth Engaging for Success With WHO-Endorsed Mental Health Approaches Among Youth Living With HIV in Ndola, Zambia

TypeinterventionalSponsorJohns Hopkins Bloomberg School of Public HealthRan2025 to 2026Enrolled323ConditionsHIV - Human Immunodeficiency Virus, Mental Health, Anxiety, Depression in AdolescenceArmsProject YES+ intervention arm
3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 1 synthesis or guideline pooled it, 63 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Article
  5. Article
  6. Building EVA (Journal of medical Internet research · 2026
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 3 countries.

Getinet AyanoResearch and Training Department, Amanuel Mental Specialized Hospital, Addis Ababa, Ethiopia. babiget2015@gmail.com.ORCID 0000-0002-9137-4141
Sileshi DemelashDepartment of Psychiatry, Paulo's Millennium Medical College, Addis Ababa, Ethiopia.
Mebratu AbrahaEthiopian Public Health Institute, Addis Ababa, Ethiopia.
Light TsegayDepartmemt of Psychiatry, Aksum University, Aksum, Ethiopia.
Aksum University · ETCurtin University · AUEthiopian Public Health Institute · ETSt. Paul's Hospital Millennium Medical College · ET

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDepression is particularly common among adolescents with HIV/AIDS and has been associated with disruption of the important developmental process, subsequently leading to a wide range of negative mental, physical and psychosocial consequences, as well as poor quality of life in those population groups. Nevertheless, to the best of our knowledge, there are no prior systematic reviews and meta-analytic studies that determined the prevalence of depression among adolescents with HIV/AIDS.

methodWe systematically searched PubMed, Scopus and Web of Science for relevant literature until May 2020. A random-effect meta-analysis was used to pool prevalence rates from individual studies. Sensitivity and subgroup analyses were performed to identify the source of heterogeneities and to compare the prevalence estimates across the groups. The Joanna Briggs Institute's quality assessment checklist was used to evaluate the quality of the included studies. Cochran's Q and the I

resultsA total of ten studies were included for the final analysis, with 2642 adolescents living with HIV/AIDS. Our final meta-analysis showed that more than a quarter of adolescents with HIV had depression [26.07% (95% CI 18.92-34.78)]. The prevalence was highest amongst female adolescents (32.15%) than males (25.07%) as well as amongst the older adolescents aged 15-19 years (37.09%) than younger adolescents aged 10-14 years (29.82%).

conclusionOur study shows that a significant proportion of adolescents with HIV had depression, indicating the imperativeness of intervention strategies to alleviate the suffering and possibly reduce the probable negative ramifications.

Indexed as

Acquired Immunodeficiency SyndromeHIV InfectionsAdolescentDepressionFemaleHumansMalePrevalenceQuality of LifeAdolescentAIDSDepressionHIVMeta-analysisSystematic review

Identifiers

PMID33906698
PMCPMC8077927
OpenAlexW3159830582

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.