ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2021
Altered regional cerebral blood flow in obstructive sleep apnea is associated with sleep fragmentation and oxygen desaturation.
Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
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Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 33 citations in OpenAlex.
- Association between sleep apnoea and risk of cognitive impairment and Alzheimer's disease: a meta-analysis of cohort-based studies.Sleep & breathing = Schlaf & Atmung · 2024Pooled it
- Obstructive sleep apnea and attention deficits: A systematic review of magnetic resonance imaging biomarkers and neuropsychological assessments.Brain and behavior · 2023Pooled it
- Exercise training reduces sympathetic nerve activity and improves executive performance in individuals with obstructive sleep apnea.Clinics (Sao Paulo, Brazil) · 2021Trial
- Sleep apnea in REM sleep as an amplifier of vascular contributions to Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Review
- Biochemical Pathways of Neuroplasticity in Sport Skill Acquisition: From Neuroscience to Coaching Practice.Brain sciences · 2026Review
- Increased MRI-derived parenchymal cerebral spinal fluid mapping in untreated obstructive sleep apnea patients.Neurobiology of disease · 2026Article
- The association between obstructive sleep apnea and total cerebral small vessel disease burden-Neurovascular insights of OSA.Frontiers in neuroscience · 2026Article
- Nano-Based Vaccine Delivery Systems: Innovative Therapeutics Against Cancer and Neurological Disorders.International journal of molecular sciences · 2025Review
- High-Fidelity MRI Assessment of Cerebral Perfusion in Healthy Neonates Less Than 1 Week of Age.Journal of magnetic resonance imaging : JMRI · 2025Article
- Programmed cell death in the cognitive impairment of obstructive sleep apnea.Cell & bioscience · 2025Review
- Association of Hypoxemia Due to Obstructive Sleep Apnea With White Matter Hyperintensities and Temporal Lobe Changes in Older Adults.Neurology · 2025Observational
- Reduced Oxygen Extraction Fraction as a Biomarker for Cognitive Deficits in Obstructive Sleep Apnea.Brain and behavior · 2025Article
- Impact of acute sleep restriction on cerebrovascular reactivity and neurovascular coupling in young men and women.Journal of applied physiology (Bethesda, Md. : 1985) · 2025Article
- Cerebrovascular autoregulation in hypoxia: quantitative insights from arterial spin labeling.Frontiers in neuroscience · 2025Review
- Cerebral perfusion is not impaired in persons with moderate obstructive sleep apnoea when awake.Sleep & breathing = Schlaf & Atmung · 2024Article
- Up-to-date advance in the relationship between OSA and stroke: a narrative review.Sleep & breathing = Schlaf & Atmung · 2024Review
- Cerebrovascular pathology mediates associations between hypoxemia during rapid eye movement sleep and medial temporal lobe structure and function in older adults.bioRxiv : the preprint server for biology · 2024Article
- Metabolic and vascular imaging markers for investigating Alzheimer's disease complicated by sleep fragmentation in mice.Frontiers in physiology · 2024Article
- Correlation between obstructive sleep apnea and hypoperfusion in patients with acute cerebral infarction.Frontiers in neurology · 2024Article
- Altered functional connectivity of the ascending reticular activating system in obstructive sleep apnea.Scientific reports · 2023Article
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
Altered cerebral perfusion has been reported in obstructive sleep apnea (OSA). Using dynamic susceptibility contrast MRI, we compared cerebral perfusion between male OSA patients and male healthy reference subjects and assessed correlations of perfusion abnormalities of OSA patients with sleep parameters and neuropsychological deficits at 3 T MRI, polysomnography and neuropsychological tests in 68 patients with OSA and 21 reference subjects. We found lower global and regional cerebral blood flow and cerebral blood volume, localized mainly in bilateral parietal and prefrontal cortices, as well as multiple focal cortical and deep structures related to the default mode network and attention network. In the correlation analysis between regional hypoperfusion and parameters of polysomnography, different patterns of regional hypoperfusion were distinctively associated with parameters of intermittent hypoxia and sleep fragmentation, which involved mainly parietal and orbitofrontal cortices, respectively. There was no association between brain perfusion and cognition in OSA patients in areas where significant association was observed in reference subjects, largely overlapping with nodes of the default mode network and attention network. Our results suggest that impaired cerebral perfusion in important areas of functional networks could be an important pathomechanism of neurocognitive deficits in OSA.
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Registered trials
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