ArticleJournal of the Royal Society, Interface2021
MRI-based quantification of ophthalmic changes in healthy volunteers during acute 15° head-down tilt as an analogue to microgravity.
Article in Journal of the Royal Society, Interface, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Lateralized cerebral arterial blood flow and blood pressure adaptations to short-term head-down tilt: a 4D flow MRI study with cognitive function assessment.Military Medical Research · 2026Article
- MReye-Seg: development and validation of an automated MRI pipeline for standardised ocular and orbital morphometrics.Eye (London, England) · 2025Article
- Understanding the relationship between intracranial pressure and spaceflight associated neuro-ocular syndrome (SANS): a systematic review.NPJ microgravity · 2025Article
- Ocular perfusion pressure is not reduced in response to lower body negative pressure.NPJ microgravity · 2024Article
- Mathematical modelling of the CSF system: effects of microstructures and posture on optic nerve subarachnoid space dynamics.Fluids and barriers of the CNS · 2022Article
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Authors and funding
9 authors.
Funding
Abstract
Spaceflight is known to cause ophthalmic changes in a condition known as spaceflight-associated neuro-ocular syndrome (SANS). It is hypothesized that SANS is caused by cephalad fluid shifts and potentially mild elevation of intracranial pressure (ICP) in microgravity. Head-down tilt (HDT) studies are a ground-based spaceflight analogue to create cephalad fluid shifts. Here, we developed non-invasive magnetic resonance imaging (MRI)-based techniques to quantify ophthalmic structural changes under acute 15° HDT. We specifically quantified: (i) change in optic nerve sheath (ONS) and optic nerve (ON) cross-sectional area, (ii) change in ON deviation, an indicator of ON tortuosity, (iii) change in vitreous chamber depth, and (iv) an estimated ONS Young's modulus. Under acute HDT, ONS cross-sectional area increased by 4.04 mm
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