Evidence map›Paper›PMID 33906372›Full record

ArticleCirculation2021

Health-Related Quality of Life and Mortality in Heart Failure: The Global Congestive Heart Failure Study of 23 000 Patients From 40 Countries.

Isabelle Johansson, Philip Joseph, Kumar Balasubramanian, John J V McMurray, Lars H Lund, Justin A Ezekowitz, Deepak Kamath, Khalid Alhabib, Antoni Bayes-Genis, Andrzej Budaj and 20 more

3 registry-linked trialsAbstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Circulation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 153 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
153citing papers in PubMed, 11 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05759000 unknown statusstarted 2023, after this paper: background citation

The Effect of Early Inpatient Initiation of Dapagliflozin on the Health-related Quality of Life of Patients With Heart Failure With All Range of Ejection Fraction: a Local Registry

Ran2023Enrolled100Registered outcomes12Posted comparisons0ConditionsHeart FailureArmsdapagliflozin
PMID 33446410PMID 20031870PMID 21156879PMID 21518742PMID 22556322PMID 23616602PMID 31535829PMID 36027570other papers from this trial
Open the trial in the graph
NCT03078166 completednot on this map

Global Congestive Heart Failure Registry

Typeobservational_patient_registrySponsorHamilton Health Sciences CorporationRan2016 to 2024Enrolled25,000ConditionsHeart Failure
NCT06921603 narecruitingnot on this mapstarted 2025, after this paper: background citation

Point-of-Care Ultrasound-Guided Diuresis for Acute Decompensated Heart Failure to Reduce 30-Day Readmissions and Acute Kidney Injury

TypeinterventionalSponsorUniversity of PittsburghRan2025 to 2026Enrolled588ConditionsHeart Decompensation, Acute, Acute Kidney InjuriesArmsFurosemide (Standard Diuretic) Treatment, POCUS-Assessed Diuretic Management
3 · Its place in the literature

Who cites it

153 citing papers in PubMed, 11 syntheses or guidelines pooled it.

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  3. Health-related quality of life of people with heart failure in low- and middle-income countries: a systematic review and meta-analysis.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2024
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93 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors.

Isabelle JohanssonPopulation Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, Canada (I.J., P.J., K.B., B.F., K.T., A.G., T.M., S.Y.).
Philip JosephPopulation Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, Canada (I.J., P.J., K.B., B.F., K.T., A.G., T.M., S.Y.).
Kumar BalasubramanianPopulation Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, Canada (I.J., P.J., K.B., B.F., K.T., A.G., T.M., S.Y.).
John J V McMurrayBHF Cardiovascular Research Centre, University of Glasgow, Scotland (J.J.V.M.).
Lars H LundDivision of Cardiology, Department of Medicine, Karolinska Institutet, Stockholm, Sweden (L.H.L.).
Justin A EzekowitzFaculty of Medicine and Dentistry, University of Alberta Canadian VIGOUR Center, University of Alberta, Edmonton, Canada (J.A.E.).
Deepak KamathDivision of Clinical Research and Training, St John's Research Institute, India (D.K.).
Khalid AlhabibDepartment of Cardiac Sciences, King Fahad Cardiac Center, College of Medicine, King Saud University, Riyadh, Saudi Arabia (K.A.).
Antoni Bayes-GenisHeart Institute, Hospital Universitari Germans Trias i Pujol, Badalona, Spain (A.B.-G.).
Andrzej BudajDepartment of Cardiology, Centre of Postgraduate Medical Education, Grochowski Hospital, Warsaw, Poland (A.B.).
Antonio L L DansDepartment of Cardiac Sciences, University of Philippines, Manila, Philippines (A.L.L.D.).
Anastase DzudieDouala General Hospital, Cameroon (A.D.).
Jefferey L ProbstfieldDivision of Cardiology, University of Washington School of Medicine, Seattle (J.L.P.).
Keith A A FoxCentre for Cardiovascular Science, University of Edinburgh, United Kingdom (K.A.A.F.).
Kamilu M KarayeDepartment of Medicine, Aminu Kano Teaching Hospital and Bayero University Kano, Nigeria (K.M.K.).
Abel MakubiMuhimbili University of Health and Allied Sciences, Dar Es Salaam, Tanzania (A.M.).
Bianca FukakusaPopulation Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, Canada (I.J., P.J., K.B., B.F., K.T., A.G., T.M., S.Y.).
Koon TeoPopulation Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, Canada (I.J., P.J., K.B., B.F., K.T., A.G., T.M., S.Y.).
Ahmet TemizhanAnkara City Hospital, Department of Cardiology, University of Health Sciences, Turkey (A.T.).
Thomas WittlingerDepartment of Cardiology, Goslar Hospital, Germany (T.W.).
Aldo P MaggioniANMCO Research Center, Associazione Nazionale Medici Cardiologi Ospedalieri, Florence, Italy (A.P.M.).
Fernando LanasUniversidad de La Frontera, Temuco, Chile (F.L.).
Patricio Lopez-JaramilloMasira Research Institute, UDES, Bucaramanga, Colombia (P.L.-J.).
José Silva-CardosoFaculty of Medicine, University of Porto, Sao Joao University Hospital Centre, Porto, Portugal (J.S.-C.).
Karen SliwaHatter Institute for Cardiovascular Research in Africa, Department of Medicine, Faculty of Health Sciences, University of Cape Town, South Africa (K.S.).
Hisham DokainishEchocardiography Laboratory, Circulate Cardiac and Vascular Centre, Burlington, Canada (H.D.).
Alex GrinvaldsPopulation Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, Canada (I.J., P.J., K.B., B.F., K.T., A.G., T.M., S.Y.).
Tara McCreadyPopulation Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, Canada (I.J., P.J., K.B., B.F., K.T., A.G., T.M., S.Y.).
Salim YusufPopulation Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, Canada (I.J., P.J., K.B., B.F., K.T., A.G., T.M., S.Y.).
G-CHF Investigators

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPoor health-related quality of life (HRQL) is common in heart failure (HF), but there are few data on HRQL in HF and the association between HRQL and mortality outside Western countries.

methodsWe used the Kansas City Cardiomyopathy Questionnaire-12 (KCCQ-12) to record HRQL in 23 291 patients with HF from 40 countries in 8 different world regions in the G-CHF study (Global Congestive Heart Failure). We compared standardized KCCQ-12 summary scores (adjusted for age, sex, and markers of HF severity) among regions (scores range from 0 to 100, with higher score indicating better HRQL). We used multivariable Cox regression with adjustment for 15 variables to assess the association between KCCQ-12 summary scores and the composite of all-cause death, HF hospitalization, and each component over a median follow-up of 1.6 years.

resultsThe mean age of participants was 65 years; 61% were men; 40% had New York Heart Association class III or IV symptoms; and 46% had left ventricular ejection fraction ≥40%. Average HRQL differed between regions (lowest in Africa [mean± SE, 39.5±0.3], highest in Western Europe [62.5±0.4]). There were 4460 (19%) deaths, 3885 (17%) HF hospitalizations, and 6949 (30%) instances of either event. Lower KCCQ-12 summary score was associated with higher risk of all outcomes; the adjusted hazard ratio (HR) for each 10-unit KCCQ-12 summary score decrement was 1.18 (95% CI, 1.17-1.20) for death. Although this association was observed in all regions, it was less marked in South Asia, South America, and Africa (weakest association in South Asia: HR, 1.08 [95% CI, 1.03-1.14]; strongest association in Eastern Europe: HR, 1.31 [95% CI, 1.21-1.42]; interaction

conclusionHRQL is a strong and independent predictor of all-cause death and HF hospitalization across all geographic regions, in mildly and severe symptomatic HF, and among patients with preserved and reduced ejection fraction. Registration: URL: https://www.clinicaltrials.gov; Unique identifier: NCT03078166.

Indexed as

AgedFemaleHeart FailureHumansMaleQuality of LifeSurvival Analysishealth statusheart failureprognosisquality of lifeventricular function, left

Identifiers

PMID33906372

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.