ArticleJournal of Korean Neurosurgical Society2021
Overview of Secondary Neurulation.
Article in Journal of Korean Neurosurgical Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 26 citations in OpenAlex.
- Surgical Treatment of Tethered Cord Syndrome by Release of Filum Terminalis: A Review.Children (Basel, Switzerland) · 2026Review
- A Peculiar Accessory Scrotum With a Human Tail-Like Structure: A Case Report.Case reports in pathology · 2026Article
- Modelling co-development between the somites and neural tube in human trunk-like structures.Nature cell biology · 2025Article
- Supracellular Mechanics and Counter-Rotational Bilateral Flows Orchestrate Posterior Morphogenesis.bioRxiv : the preprint server for biology · 2025Article
- Breed-specific variations in canine spinal cord anatomy: conus medullaris and dural sac termination and filum terminale internum length.BMC veterinary research · 2025Article
- Proteomic Characterization of Extracellular Vesicles from Human Neural Precursor Cells: A Promising Advanced Therapy for Neurodegenerative Diseases.International journal of nanomedicine · 2025Article
- Article
- Image characteristics of retained medullary cord in secondary neurulation arrest: an observational study.Scientific reports · 2024Observational
- Multidisciplinary management of people with spina bifida across the lifespan.Pediatric nephrology (Berlin, Germany) · 2024Review
- Case Report: Two cases of multiples and atypical dermal sinus tracts.Frontiers in pediatrics · 2024Article
- Constructing the pharyngula: Connecting the primary axial tissues of the head with the posterior axial tissues of the tail.Cells & development · 2023Review
- The loop-tail mouse model displays open and closed caudal neural tube defects.Disease models & mechanisms · 2023Article
- Topological morphogenesis of neuroepithelial organoids.Nature physics · 2023Article
- Myelomeningocele as an anomaly of secondary neurulation.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2022Article
- Pathogenesis of neural tube defects: The regulation and disruption of cellular processes underlying neural tube closure.WIREs mechanisms of disease · 2022Review
- Overview of Neural Tube Defects: Gene-Environment Interactions, Preventative Approaches and Future Perspectives.Biomedicines · 2022Review
- Embryology of the Abdominal Wall and Associated Malformations-A Review.Frontiers in surgery · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Secondary neurulation is a morphological process described since the second half of the 19th century; it accounts for the formation of the caudal spinal cord in mammals including humans. A similar process takes place in birds. This form of neurulation is caused by the growth of the tail bud region, the most caudal axial region of the embryo. Experimental work in different animal species leads to questioning dogmas widely disseminated in the medical literature. Thus, it is clearly established that the tail bud is not a mass of undifferentiated pluripotent cells but is made up of a juxtaposition of territories whose fate is different. The lumens of the two tubes generated by the two modes of neurulation are continuous. There seem to be multiple cavities in the human embryo, but discrepancies exist according to the authors. Finally, the tissues that generate the secondary neural tube are initially located in the most superficial layer of the embryo. These cells must undergo internalization to generate the secondary neurectoderm. A defect in internalization could lead to an open neural tube defect that contradicts the dogma that a secondary neurulation defect is closed by definition.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.