ArticleJournal of Korean Neurosurgical Society2021
Disorders of Secondary Neurulation : Mainly Focused on Pathoembryogenesis.
Article in Journal of Korean Neurosurgical Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 21 citations in OpenAlex.
- Multiple congenital dermal sinus tracts: a case-based review involving a unique triple-tract configuration that challenges current embryological concepts.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2026Review
- Co-existing limited dorsal myeloschisis, spinal dermal sinus tract, and dermoid cyst in a 3-month-old female infant: Illustrative case.Radiology case reports · 2026Article
- Neurosurgical management of a giant anterior sacral meningocele in a patient with combined Currarino syndrome and caudal duplication anomaly: illustrative case.Journal of neurosurgery. Case lessons · 2025Article
- Fundamental origins of neural tube defects with a basis in genetics and nutrition.Experimental brain research · 2025Review
- Association of spinal cord abnormalities with vertebral anomalies: an embryological perspective.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2024Article
- Cartilage within lipomyelomeningocele and ulnar longitudinal deficiency syndrome as VACTERL association, alliance in SHH/GLI3, and Wnt pathway: illustrative case.Journal of neurosurgery. Case lessons · 2024Article
- Fibrous hamartoma of infancy of the spinal cord resembling conus and filum, with a coexisting sacral dimple.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2024Article
- Surgery for spina bifida occulta: spinal lipoma and tethered spinal cord.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2023Review
- Limited dorsal myeloschisis associated with intramedullary infantile hemangioma in the conus medullaris: illustrative case.Journal of neurosurgery. Case lessons · 2023Article
- Secondary Neurulation Defects: Retained Medullary Cord.Advances and technical standards in neurosurgery · 2023Article
- Ectopic dorsal root ganglion in cauda equina mimicking schwannoma in a child.Surgical neurology international · 2023Article
- Retained medullary cord and caudal lipoma with histopathological presence of terminal myelocystocele in the epidural stalk.Surgical neurology international · 2023Article
- Myelomeningocele as an anomaly of secondary neurulation.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2022Article
- Retained medullary cord and terminal myelocystocele as a spectrum: case report.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2022Article
- Intramedullary abscess at thoracolumbar region transmitted from infected dermal sinus and dermoid through retained medullary cord.Surgical neurology international · 2022Article
- Disorders of Secondary Neurulation: Suggestion of a New Classification According to Pathoembryogenesis.Advances and technical standards in neurosurgery · 2022Article
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent advancements in basic research on the process of secondary neurulation and increased clinical experience with caudal spinal anomalies with associated abnormalities in the surrounding and distal structures shed light on further understanding of the pathoembryogenesis of the lesions and led to the new classification of these dysraphic entities. We summarized the changing concepts of lesions developed from the disordered secondary neurulation shown during the last decade. In addition, we suggested our new pathoembryogenetic explanations for a few entities based on the literature and the data from our previous animal research. Disordered secondary neurulation at each phase of development may cause corresponding lesions, such as failed junction with the primary neural tube (junctional neural tube defect and segmental spinal dysgenesis), dysgenesis or duplication of the caudal cell mass associated with disturbed activity of caudal mesenchymal tissue (caudal agenesis and caudal duplication syndrome), failed ingression of the primitive streak to the caudal cell mass (myelomeningocele), focal limited dorsal neuro-cutaneous nondisjunction (limited dorsal myeloschisis and congenital dermal sinus), neuro-mesenchymal adhesion (lumbosacral lipomatous malformation), and regression failure spectrum of the medullary cord (thickened filum and filar cyst, low-lying conus, retained medullary cord, terminal myelocele and terminal myelocystocele). It seems that almost every anomalous entity of the primary neural tube may occur in the area of secondary neurulation. Furthermore, the close association with the activity of caudal mesenchymal tissue in secondary neurulation involves a wider range of surrounding structures than in primary neurulation. Although the majority of the data are from animals, not from humans and many theories are still conjectural, these changing concepts of normal and disordered secondary neurulation will provoke further advancements in our management strategies as well as in the pathoembryogenetic understanding of anomalous lesions in this area.
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