Evidence map›Paper›PMID 33905891›Full record

ArticleInfection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases2021

Spike protein mutational landscape in India during the complete lockdown phase: Could Muller's ratchet be a future game-changer for COVID-19?

Rachana Banerjee, Kausik Basak, Anamika Ghosh, Vyshakh Rajachandran, Kamakshi Sureka, Debabani Ganguly, Sujay Chattopadhyay

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Rachana BanerjeeCentre for Health Science and Technology, JIS Institute of Advanced Studies and Research Kolkata, JIS University, Kolkata 700091, West Bengal, India.
Kausik BasakCentre for Health Science and Technology, JIS Institute of Advanced Studies and Research Kolkata, JIS University, Kolkata 700091, West Bengal, India.
Anamika GhoshDepartment of Chemistry, Indian Institute of Engineering Science and Technology, Shibpur, Howrah, 711103, West Bengal, India.
Vyshakh RajachandranCentre for Health Science and Technology, JIS Institute of Advanced Studies and Research Kolkata, JIS University, Kolkata 700091, West Bengal, India.
Kamakshi SurekaCentre for Health Science and Technology, JIS Institute of Advanced Studies and Research Kolkata, JIS University, Kolkata 700091, West Bengal, India.
Debabani GangulyCentre for Health Science and Technology, JIS Institute of Advanced Studies and Research Kolkata, JIS University, Kolkata 700091, West Bengal, India. Electronic address: debabani@jisiasr.org.
Sujay ChattopadhyayCentre for Health Science and Technology, JIS Institute of Advanced Studies and Research Kolkata, JIS University, Kolkata 700091, West Bengal, India. Electronic address: sujayc@jisiasr.org.
Indian Institute of Engineering Science and Technology, Shibpur · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The dire need of effective preventive measures and treatment approaches against SARS-CoV-2 virus, causing COVID-19 pandemic, calls for an in-depth understanding of its evolutionary dynamics with attention to specific geographic locations, since lockdown and social distancing to prevent the virus spread could lead to distinct localized dynamics of virus evolution within and between countries owing to different environmental and host-specific selection pressures. To decipher any correlation between SARS-CoV-2 evolution and its epidemiology in India, we studied the mutational diversity of spike glycoprotein, the key player for the attachment, fusion and entry of virus to the host cell. For this, we analyzed the sequences of 630 Indian isolates as available in GISAID database till June 07, 2020 (during the time-period before the start of Unlock 1.0 in India on and from June 08, 2020), and detected the spike protein variants to emerge from two major ancestors - Wuhan-Hu-1/2019 and its D614G variant. Average stability of the docked spike protein - host receptor (S-R) complexes for these variants correlated strongly (R

Indexed as

MutationBiological EvolutionCOVID-19HumansIndiaQuarantineSARS-CoV-2Spike Glycoprotein, CoronavirusSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2Molecular dockingMuller's ratchetMutational meltdownSARS-CoV-2Viral evolutionary dynamics

Identifiers

PMID33905891
PMCPMC8084351
OpenAlexW3157887850

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.