ArticleNeuroImage2021
Estimates of locus coeruleus function with functional magnetic resonance imaging are influenced by localization approaches and the use of multi-echo data.
Article in NeuroImage, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
26 citing papers in PubMed, 38 citations in OpenAlex.
- BOLD fMRI activations and LC contrast associated with successful episodic memory in healthy older adults and MCI.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Resolving mesoscale brainstem-prefrontal-striatal pathways underlying decisions upon salient events using submillimeter-resolution fMRI.Nature communications · 2026Article
- Roles of target detection and behavioral response on pupil dilation and concurrent memory: An attentional boost study.Attention, perception & psychophysics · 2026Article
- The quest for the best: manual, atlas- and spatial prior-based delineation of locus coeruleus.NeuroImage. Clinical · 2026Article
- Inverse Association of Locus Coeruleus MRI Integrity With Structural Volume and Its Impact on Individual's Inattentiveness.Human brain mapping · 2025Article
- Blood oxygenation level-dependent responses in neuromodulatory nuclei and their associations with attention and memory across age groups.Neurobiology of aging · 2025Article
- The Locus Coeruleus-Noradrenergic System in the Healthy and Diseased Brain: A Narrative Review.European journal of neurology · 2025Review
- Neuropeptides as transmitters and regulators of the locus coeruleus noradrenergic system.Pharmacological reviews · 2025Review
- Age-related differences in locus coeruleus intensity across a demographically diverse sample.Neurobiology of aging · 2025Article
- Multimodal state-dependent connectivity analysis of arousal and autonomic centers in the brainstem and basal forebrain.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Pathological and neurochemical correlates of locus coeruleus functional network activity.Biological psychology · 2024Article
- Simultaneous cortical, subcortical, and brainstem mapping of sensory activation.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Simultaneous cortical, subcortical, and brainstem mapping of sensory activation.bioRxiv : the preprint server for biology · 2024Article
- Nonlinear changes in pupillary attentional orienting responses across the lifespan.GeroScience · 2024Article
- Locus coeruleus neuromelanin accumulation and dissipation across the lifespan.bioRxiv : the preprint server for biology · 2023Article
- Pupil size reflects activation of subcortical ascending arousal system nuclei during rest.eLife · 2023Article
- State-of-the-art imaging of neuromodulatory subcortical systems in aging and Alzheimer's disease: Challenges and opportunities.Neuroscience and biobehavioral reviews · 2023Review
- Tonic and phasic effects of reward on the pupil: implications for locus coeruleus function.Proceedings. Biological sciences · 2022Article
- The influence of the subcortex and brain stem on overeating: How advances in functional neuroimaging can be applied to expand neurobiological models to beyond the cortex.Reviews in endocrine & metabolic disorders · 2022Review
- Effects of reciprocal inhibition and whole-body relaxation on persistent inward currents estimated by two different methods.The Journal of physiology · 2022Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
The locus coeruleus (LC) plays a central role in regulating human cognition, arousal, and autonomic states. Efforts to characterize the LC's function in humans using functional magnetic resonance imaging have been hampered by its small size and location near a large source of noise, the fourth ventricle. We tested whether the ability to characterize LC function is improved by employing neuromelanin-T1 weighted images (nmT1) for LC localization and multi-echo functional magnetic resonance imaging (ME-fMRI) for estimating intrinsic functional connectivity (iFC). Analyses indicated that, relative to a probabilistic atlas, utilizing nmT1 images to individually localize the LC increases the specificity of seed time series and clusters in the iFC maps. When combined with independent components analysis (ME-ICA), ME-fMRI data provided significant improvements in the temporal signal to noise ratio and DVARS relative to denoised single echo data (1E-fMRI). The effects of acquiring nmT1 images and ME-fMRI data did not appear to only reflect increases in power: iFC maps for each approach overlapped only moderately. This is consistent with findings that ME-fMRI offers substantial advantages over 1E-fMRI acquisition and denoising. It also suggests that individually identifying LC with nmT1 scans is likely to reduce the influence of other nearby brainstem regions on estimates of LC function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.