Evidence map›Paper›PMID 33905633›Full record

SynthesisArchives of endocrinology and metabolism2021

Efficacy of exercise on balance, fear of falling, and risk of falls in patients with diabetic peripheral neuropathy: a systematic review and meta-analysis.

Renata Aparecida de Oliveira Lima, Gabriela Andrade Piemonte, Célia Regina Nogueira, Vania Dos Santos Nunes-Nogueira

Registry-linked trialOpen access · diamondAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Archives of endocrinology and metabolism, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07576179 (Comparative Effects of Plantar Intrinsic Muscles Exercises and 3-dimensional Ankle Foot Exercises on Balance, Gait and Fall Risk in Patients With Diabetic Peripheral Neuropathy), which is not on this map. Cited by 15 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 4 pooled it
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07576179 narecruitingnot on this mapstarted 2026, after this paper: background citation

Comparative Effects of Plantar Intrinsic Muscles Exercises and 3-dimensional Ankle Foot Exercises on Balance, Gait and Fall Risk in Patients With Diabetic Peripheral Neuropathy

TypeinterventionalSponsorRiphah International UniversityRan2026 to 2026Enrolled40ConditionsDiabetic Peripheral Neuropathy (DPN)ArmsPlantar intrinsic foot exercises, Three-Dimensional ankle foot exercises
3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 4 syntheses or guidelines pooled it, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Renata Aparecida de Oliveira LimaFisioterapia pela Universidade do Oeste Paulista, Presidente Prudente, SP, Brasil.
Gabriela Andrade PiemonteFisioterapia pela Universidade do Oeste Paulista, Presidente Prudente, SP, Brasil.
Célia Regina NogueiraDepartamento de Clínica Médica, Universidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatu, SP, Brasil.
Vania Dos Santos Nunes-NogueiraDepartamento de Clínica Médica, Universidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatu, SP, Brasil, vania.nunes-nogueira@unesp.br.
Universidade do Oeste Paulista · BRUniversidade Estadual Paulista (Unesp) · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetic peripheral neuropathy (DPN) is the most common complication of diabetes mellitus. Our objective was to evaluate the efficacy of exercise interventions in DPN patients from randomized controlled trials. The primary outcomes were the risk of falls, fear of falling, balance and quality of life. Two reviewers independently selected studies from Embase, Medline, LILACS, CENTRAL, and PEDro. They assessed the risk of bias and extracted data from the trials. The relative risk (RR) and the differences between means (MD) were calculated with a 95% confidence interval (CI) and used as the effect size. We used a random-effects model to pool results across studies, and the Grading of Recommendations Assessment, Development, and Evaluation system to evaluate the certainty of evidence. Eight trials were included. No clear effect was observed in the risk of falls (RR: 0.93, 95% CI: 0.41 to 2.09, 79 participants, 1 trial,

Indexed as

Diabetes MellitusDiabetic NeuropathiesAccidental FallsExerciseFearHumansQuality of LifebalanceDiabetic peripheral neuropathyexercisefallssystematic review

Identifiers

PMID33905633
PMCPMC10065320
OpenAlexW3134036276

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.