Evidence map›Paper›PMID 33905165›Full record

ArticleChemistry (Weinheim an der Bergstrasse, Germany)2021

Accessing Improbable Foldamer Shapes with Strained Macrocycles.

Ko Urushibara, Yann Ferrand, Zhiwei Liu, Kosuke Katagiri, Masatoshi Kawahata, Estelle Morvan, Ryan D'Elia, Vojislava Pophristic, Aya Tanatani, Ivan Huc

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Accessing Improbable Foldamer Shapes with Strained Macrocycles.Chemistry (Weinheim an der Bergstrasse, Germany) · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ko UrushibaraDepartment of Chemistry, Faculty of Science, Ochanomizu University, 2-1-1 Otsuka, Bunkyo-ku, Tokyo, 112-8610, Japan.ORCID http://orcid.org/0000-0001-9600-7343
Yann FerrandCBMN (UMR 5248), Université de Bordeaux, CNRS, Bordeaux Institut National Polytechnique, 2 rue Robert Escarpit, 33600, Pessac, France.ORCID http://orcid.org/0000-0002-6552-6914
Zhiwei LiuDepartment of Chemistry & Biochemistry, University of the Sciences, 600 South 43rd Street, Philadelphia, PA, 19104, USA.
Kosuke KatagiriDepartment of Chemistry, Faculty of Science and Engineering, Konan University, 8-9-1 Okamoto, Higashinada-ku, Kobe, 658-8501, Japan.ORCID http://orcid.org/0000-0002-3871-619X
Masatoshi KawahataFaculty of Pharmaceutical Sciences, Showa Pharmaceutical University, 3-3165 Higashi-Tamagawagakuen, Machida, Tokyo, 194-8543, Japan.ORCID http://orcid.org/0000-0003-2865-4113
Estelle MorvanIECB (UMS3033/US001), Université de Bordeaux, CNRS, INSERM, 2 rue Robert Escarpit, 33600, Pessac, France.
Ryan D'EliaDepartment of Chemistry & Biochemistry, University of the Sciences, 600 South 43rd Street, Philadelphia, PA, 19104, USA.
Vojislava PophristicDepartment of Chemistry & Biochemistry, University of the Sciences, 600 South 43rd Street, Philadelphia, PA, 19104, USA.
Aya TanataniDepartment of Chemistry, Faculty of Science, Ochanomizu University, 2-1-1 Otsuka, Bunkyo-ku, Tokyo, 112-8610, Japan.ORCID http://orcid.org/0000-0002-6667-8506
Ivan HucCBMN (UMR 5248), Université de Bordeaux, CNRS, Bordeaux Institut National Polytechnique, 2 rue Robert Escarpit, 33600, Pessac, France.ORCID http://orcid.org/0000-0001-7036-9696

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The alkylation of some secondary amide functions with a dimethoxybenzyl (DMB) group in oligomers of 8-amino-2-quinolinecarboxylic acid destabilizes the otherwise favored helical conformations, and allows for cyclization to take place. A cyclic hexamer and a cyclic heptamer were produced in this manner. After DMB removal, X-ray crystallography and NMR show that the macrocycles adopt strained conformations that would be improbable in noncyclic species. The high helix folding propensity of the main chain is partly expressed in these conformations, but it remains frustrated by macrocyclization. Despite being homomeric, the macrocycles possess inequivalent monomer units. Experimental and computational studies highlight specific fluxional pathways within these structures. Extensive simulated annealing molecular dynamics allow for the prediction of the conformations for larger macrocycles with up to sixteen monomers.

Indexed as

AmidesCrystallography, X-RayCyclizationModels, MolecularMolecular ConformationAmidescis amidefluxionalityfoldamermacrocyclestrained structures

Identifiers

PMID33905165
PMCPMC8453500

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.