Evidence map›Paper›PMID 33905162›Full record

ArticleChemMedChem2021

A Structure-Activity Relationship Study of Bimodal BODIPY-Labeled PSMA-Targeting Bioconjugates.

Tobias Stemler, Caroline Hoffmann, Ina M Hierlmeier, Stephan Maus, Elmar Krause, Samer Ezziddin, Gregor Jung, Mark D Bartholomä

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ChemMedChem, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Tobias StemlerDepartment of Nuclear Medicine, Saarland University - Medical Center, Kirrbergerstrasse, 66421, Homburg, Germany.
Caroline HoffmannDepartment of Biophysical Chemistry, Saarland University, Campus B2 2, 66123, Saarbrücken, Germany.
Ina M HierlmeierDepartment of Nuclear Medicine, Saarland University - Medical Center, Kirrbergerstrasse, 66421, Homburg, Germany.
Stephan MausDepartment of Nuclear Medicine, Saarland University - Medical Center, Kirrbergerstrasse, 66421, Homburg, Germany.
Elmar KrauseDepartment of Cellular Neurophysiology, Center for Integrative Physiology and Molecular Medicine (CIPMM), Saarland University, Kirrbergerstrasse, 66421, Homburg, Germany.ORCID 0000-0003-0891-2373
Samer EzziddinDepartment of Nuclear Medicine, Saarland University - Medical Center, Kirrbergerstrasse, 66421, Homburg, Germany.
Gregor JungDepartment of Biophysical Chemistry, Saarland University, Campus B2 2, 66123, Saarbrücken, Germany.
Mark D BartholomäDepartment of Nuclear Medicine, Saarland University - Medical Center, Kirrbergerstrasse, 66421, Homburg, Germany.ORCID 0000-0002-0361-2833
Saarland University · DE

Funding

German Science Foundation INST 256/506-1German Science Foundation JU650/10-HOMFOR program of Saarland UniversitySaarland University
6 · The paper itself

Abstract

The aim of this study was to identify a high-affinity BODIPY peptidomimetic that targets the prostate-specific membrane antigen (PSMA) as a potential bimodal imaging probe for prostate cancer. For the structure-activity study, several BODIPY (difluoroboron dipyrromethene) derivatives with varying spacers between the BODIPY dye and the PSMA Glu-CO-Lys binding motif were prepared. Corresponding affinities were determined by competitive binding assays in PSMA-positive LNCaP cells. One compound was identified with comparable affinity (IC

Indexed as

Antigens, SurfaceBoron CompoundsDose-Response Relationship, DrugGlutamate Carboxypeptidase IIHumansMaleMicroscopy, FluorescenceMolecular StructurePeptidomimeticsPositron-Emission TomographyProstatic NeoplasmsStructure-Activity Relationship4,4-difluoro-4-bora-3a,4a-diaza-s-indaceneAntigens, SurfaceBoron CompoundsFOLH1 protein, humanGlutamate Carboxypeptidase IIPeptidomimeticsbimodal imagingBODIPYfluorescence imagingPETPSMA

Identifiers

PMID33905162
PMCPMC8453963
OpenAlexW3159971171

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.