ArticleJournal of neuro-oncology2021
High-grade astrocytoma with piloid features (HGAP): the Charité experience with a new central nervous system tumor entity.
Article in Journal of neuro-oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
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54 citing papers in PubMed, 76 citations in OpenAlex.
- High-grade astrocytoma with piloid features: A clinical and genomic analysis of prognostic factors using a large cohort.Neuro-oncology · 2026Article
- Comparison between molecular and histological IDH-wild-type glioblastoma and extensive subgroup analysis of IDH-wild-type astrocytic tumors without genomic glioblastoma-defining alterations.Journal of neuro-oncology · 2026Article
- Magnetic Resonance Imaging Features in Intramedullary Tumors: A Pictorial Review.Biomedicines · 2026Article
- Large-Scale Assessment ofbioRxiv : the preprint server for biology · 2026Article
- MEK inhibitors for neurofibromatosis type 1-associated central and peripheral nervous system tumors.Neuro-oncology advances · 2026Review
- MEK inhibition in adult patients with pilocytic astrocytomas.NPJ precision oncology · 2026Article
- High-Grade Astrocytoma With Piloid Features: An Aggressive Clinicogenomic Entity Distinct From Pilocytic Astrocytoma.Journal of Korean medical science · 2026Article
- Clinical potential of [European journal of nuclear medicine and molecular imaging · 2026Article
- High-grade astrocytoma with piloid features: a case report of comprehensive management.Frontiers in oncology · 2026Article
- Artificial intelligence in cancer: applications, challenges, and future perspectives.Molecular cancer · 2025Review
- Adult pilocytic astrocytomas: challenging the benign paradigm with surgical risks, recurrence dynamics, and molecular insights.Neurosurgical review · 2025Article
- High-grade astrocytoma with piloid features resected with an exoscopic supracerebellar infratentorial approach: illustrative case.Journal of neurosurgery. Case lessons · 2025Article
- The therapeutic efficacy and application prospects of tumor-treating fields (TTFields) in resolving malignant tumors of central nervous system.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2025Review
- ATRX loss in adult gliomas lacking H3 alterations or IDH mutations, an exceptional situation for exceptional diagnoses: the experience of Sainte-Anne hospital.Acta neuropathologica communications · 2025Article
- Reclassification of pineal tumor as high-grade astrocytoma with piloid features through methylation profiling: illustrative case.Journal of neurosurgery. Case lessons · 2025Article
- High-grade astrocytoma with piloid features: a single-institution case series and literature review.Acta neuropathologica communications · 2025Review
- High-grade astrocytoma with piloid features: A case report and review of literature.Surgical neurology international · 2025Article
- High-grade astrocytoma with piloid features: MRI findings associated with a novel entity.Radiology case reports · 2024Article
- Freiburg Neuropathology Case Conference : Posterior fossa tumour 15 years after microsurgical resection of a cerebellar pilocytic astrocytoma.Clinical neuroradiology · 2024Article
- High-grade astrocytoma with piloid features in the conus medullaris: a rare presentation of a new World Health Organization diagnosis. Illustrative case.Journal of neurosurgery. Case lessons · 2024Article
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeHigh-grade astrocytoma with piloid features (HGAP) is a recently described brain tumor entity defined by a specific DNA methylation profile. HGAP has been proposed to be integrated in the upcoming World Health Organization classification of central nervous system tumors expected in 2021. In this series, we present the first single-center experience with this new entity.
methodsDuring 2017 and 2020, six HGAP were identified. Clinical course, surgical procedure, histopathology, genome-wide DNA methylation analysis, imaging, and adjuvant therapy were collected.
resultsTumors were localized in the brain stem (n = 1), cerebellar peduncle (n = 1), diencephalon (n = 1), mesencephalon (n = 1), cerebrum (n = 1) and the thoracic spinal cord (n = 2). The lesions typically presented as T1w hypo- to isointense and T2w hyperintense with inhomogeneous contrast enhancement on MRI. All patients underwent initial surgical intervention. Three patients received adjuvant radiochemotherapy, and one patient adjuvant radiotherapy alone. Four patients died of disease, with an overall survival of 1.8, 9.1, 14.8 and 18.1 months. One patient was alive at the time of last follow-up, 14.6 months after surgery, and one patient was lost to follow-up. Apart from one tumor, the lesions did not present with high grade histology, however patients showed poor clinical outcomes.
conclusionsHere, we provide detailed clinical, neuroradiological, histological, and molecular pathological information which might aid in clinical decision making until larger case series are published. With the exception of one case, the tumors did not present with high-grade histology but patients still showed short intervals between diagnosis and tumor progression or death even after extensive multimodal therapy.
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