Evidence map›Paper›PMID 33905029›Full record

ArticleWiener klinische Wochenschrift2021

Attenuation of COVID-19-induced cytokine storm in a young male patient with severe respiratory and neurological symptoms.

Christian Muschitz, Anita Trummert, Theresa Berent, Norbert Laimer, Lukas Knoblich, Gerd Bodlaj, Alexander Krainer, Christoph Linder, Heinrich Resch

Abstract readCase Reports
In one paragraph

Article in Wiener klinische Wochenschrift, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Christian MuschitzMedical Department II-the VINFORCE Study Group, Academic Teaching Hospital of the Medical University of Vienna, St. Vincent Hospital Vienna, Stumpergasse 13, 1060, Vienna, Austria. christian.muschitz@bhs.at.ORCID http://orcid.org/0000-0002-4105-5361
Anita TrummertDepartment of Neurology, Divine Savior Hospital Vienna, Dornbacher Straße 20-30, 1170, Vienna, Austria.
Theresa BerentMedical Department II-the VINFORCE Study Group, Academic Teaching Hospital of the Medical University of Vienna, St. Vincent Hospital Vienna, Stumpergasse 13, 1060, Vienna, Austria.
Norbert LaimerMedical Department II-the VINFORCE Study Group, Academic Teaching Hospital of the Medical University of Vienna, St. Vincent Hospital Vienna, Stumpergasse 13, 1060, Vienna, Austria.
Lukas KnoblichMedical Department II-the VINFORCE Study Group, Academic Teaching Hospital of the Medical University of Vienna, St. Vincent Hospital Vienna, Stumpergasse 13, 1060, Vienna, Austria.
Gerd BodlajMedical Department II-the VINFORCE Study Group, Academic Teaching Hospital of the Medical University of Vienna, St. Vincent Hospital Vienna, Stumpergasse 13, 1060, Vienna, Austria.
Alexander KrainerDepartment of Anesthesiology, St. Vincent Hospital Vienna, Stumpergasse 13, 1170, Vienna, Austria.
Christoph LinderDepartment of Neurology, Divine Savior Hospital Vienna, Dornbacher Straße 20-30, 1170, Vienna, Austria.
Heinrich ReschMedical Department II-the VINFORCE Study Group, Academic Teaching Hospital of the Medical University of Vienna, St. Vincent Hospital Vienna, Stumpergasse 13, 1060, Vienna, Austria.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2), the etiological agent of coronavirus disease 2019 (COVID-19), produces protean manifestations and causes indiscriminate havoc in multiple organ systems. This rapid and vast production of proinflammatory cytokines contributes to a condition termed cytokine storm. A 35-year-old, otherwise healthy, employed, male patient was tested positive for COVID-19. He was admitted to the hospital on disease day 10 due to retarded verbal reactions and progressive delirium. On account of these conditions and the need for noninvasive/invasive ventilation, a combination treatment with baricitinib and remdesivir in conjunction with standard of care was initiated. The cytokine storm was rapidly blocked, leading to a vast pulmonary recovery with retarded recovery of the central nervous system. We conclude that the rapid blockade of the COVID-19-induced cytokine storm should be considered of avail as a principle of careful decision-making for effective recovery.

Indexed as

COVID-19Cytokine Release SyndromeAdultCytokinesHumansMaleSARS-CoV-2CytokinesBaricitinibCOVID-19Cytokine stormInflammationRemdesivir

Identifiers

PMID33905029
PMCPMC8076667

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.