Evidence map›Paper›PMID 33904978›Full record

ArticleEuropean archives of psychiatry and clinical neuroscience2021

Hostility in medication-resistant major depression and comorbid generalized anxiety disorder is related to increased hippocampal-amygdala 5-HT

Chris Baeken, Yanfeng Xu, Guo-Rong Wu, Robrecht Dockx, Kathelijne Peremans, Rudi De Raedt

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European archives of psychiatry and clinical neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Analysis of brain signal change response in amygdala evoked by skin pressure stimulus.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2023
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 3 countries.

Chris BaekenDepartment of Psychiatry and Medical Psychology, Ghent Experimental Psychiatry (GHEP) Lab, Ghent University, Ghent, Belgium.ORCID http://orcid.org/0000-0001-9885-3041
Yanfeng XuDepartment of Psychiatry and Medical Psychology, Ghent Experimental Psychiatry (GHEP) Lab, Ghent University, Ghent, Belgium.
Guo-Rong WuKey Laboratory of Cognition and Personality, Faculty of Psychology, Southwest University, Chongqing, China. gronwu@gmail.com.
Robrecht DockxDepartment of Nutrition, Genetics and Ethology, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.
Kathelijne PeremansDepartment of Veterinary Medical Imaging and Small Animal Orthopaedics, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.
Rudi De RaedtDepartment of Experimental Clinical and Health Psychology, Ghent University, Ghent, Belgium.
Ghent University · BEGhent University Hospital · BESouthwest University · CNVrije Universiteit Brussel · BE

Funding

Concerted Research Action of Ghent University BOF16/GOA/017National Natural Science Foundation of China Grant No. 61876156
6 · The paper itself

Abstract

Major depressive disorder (MDD) and generalized anxiety disorder (GAD) are severe and difficult-to-treat psychiatric illnesses with high rates of comorbidity. Although both disorders are treated with serotonergic based psychotropic agents, little is known on the influence of the serotonergic neurotransmitter system on the occurrence of comorbid GAD when clinically depressed. To investigate this poorly understood clinical question, we examined the involvement of frontolimbic post-synaptic 5-HT

Indexed as

Anxiety DisordersDepressive Disorder, Treatment-ResistantHostilityMajor Depressive DisorderReceptor, Serotonin, 5-HT2AAmygdalaComorbidityHippocampusHumansReceptor, Serotonin, 5-HT2AComorbidityGeneralized anxiety disorderMajor depressive disorderR91150 SPECTserotonin 5-HT2A receptor

Identifiers

PMID33904978
PMCPMC8429407
OpenAlexW3157892935

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.