Evidence map›Paper›PMID 33904966›Full record

Trial reportJournal of neurology2021

Memory enhancement by multidomain group cognitive training in patients with Parkinson's disease and mild cognitive impairment: long-term effects of a multicenter randomized controlled trial.

Nele Schmidt, Inken Tödt, Daniela Berg, Christian Schlenstedt, Ann-Kristin Folkerts, Anja Ophey, Karina Dimenshteyn, Saskia Elben, Lars Wojtecki, Inga Liepelt-Scarfone and 5 more

Open access · hybridAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 3 pooled it
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 3 syntheses or guidelines pooled it, 21 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 9 institutions in 1 country.

Nele SchmidtDepartment of Neurology, University Oldenburg, Steinweg 13-17, 26122, Oldenburg, Germany.
Inken TödtDepartment of Neurology, University Hospital Schleswig-Holstein, Christian-Albrechts-University, Kiel, Germany.
Daniela BergDepartment of Neurology, University Hospital Schleswig-Holstein, Christian-Albrechts-University, Kiel, Germany.
Christian SchlenstedtDepartment of Neurology, University Hospital Schleswig-Holstein, Christian-Albrechts-University, Kiel, Germany.
Ann-Kristin FolkertsMedical Psychology, Neuropsychology and Gender Studies, Center for Neuropsychological Diagnostics and Interventions (CeNDI), Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Anja OpheyMedical Psychology, Neuropsychology and Gender Studies, Center for Neuropsychological Diagnostics and Interventions (CeNDI), Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Karina DimenshteynDepartment of Neurology, Center for Movement Disorders and Neuromodulation and Institute of Clinical Neuroscience and Medical Psychology, Medical Faculty, Heinrich-Heine-University Duesseldorf, Duesseldorf, Germany.
Saskia ElbenDepartment of Neurology, Center for Movement Disorders and Neuromodulation and Institute of Clinical Neuroscience and Medical Psychology, Medical Faculty, Heinrich-Heine-University Duesseldorf, Duesseldorf, Germany.
Lars WojteckiDepartment of Neurology, Center for Movement Disorders and Neuromodulation and Institute of Clinical Neuroscience and Medical Psychology, Medical Faculty, Heinrich-Heine-University Duesseldorf, Duesseldorf, Germany.
Inga Liepelt-ScarfoneDepartment of Neurodegenerative Diseases, German Center for Neurodegenerative Diseases (DZNE) and Hertie Institute for Clinical Brain Research, University of Tuebingen, Tuebingen, Germany.
Claudia SchulteDepartment of Neurodegenerative Diseases, German Center for Neurodegenerative Diseases (DZNE) and Hertie Institute for Clinical Brain Research, University of Tuebingen, Tuebingen, Germany.
Patricia SulzerDepartment of Neurodegenerative Diseases, German Center for Neurodegenerative Diseases (DZNE) and Hertie Institute for Clinical Brain Research, University of Tuebingen, Tuebingen, Germany.
Carsten EggersDepartment of Neurology, University Hospital of Marburg, Center for Mind, Brain and Behavior (CMBB), Universities Marburg and Giessen, Marburg, Germany.
Elke Kalbe *Medical Psychology, Neuropsychology and Gender Studies, Center for Neuropsychological Diagnostics and Interventions (CeNDI), Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Karsten Witt *Department of Neurology, University Oldenburg, Steinweg 13-17, 26122, Oldenburg, Germany. karsten.witt@uni-oldenburg.de.
Heinrich Heine University Düsseldorf · DEUniversity of Cologne · DEGerman Center for Neurodegenerative Diseases · DEKiel University · DECarl von Ossietzky Universität Oldenburg · DEHertie Institute for Clinical Brain Research · DEUniversity Hospital Cologne · DEUniversity Hospital Schleswig-Holstein · DEUniversity of Lübeck · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMeta-analyses indicate positive effects of cognitive training (CT) in patients with Parkinson's disease (PD), however, most previous studies had small sample sizes and did not evaluate long-term follow-up. Therefore, a multicenter randomized controlled, single-blinded trial (Train-ParC study) was conducted to examine CT effects in PD patients with mild cognitive impairment (PD-MCI). Immediately after CT, an enhancement of executive functions was demonstrated. Here, we present the long-term results 6 and 12 months after CT.

methodsAt baseline, 64 PD-MCI patients were randomized to a multidomain CT group (n = 33) or to a low-intensity physical activity training control group (PT) (n = 31). Both interventions included 90 min training sessions twice a week for 6 weeks. 54 patients completed the 6 months (CT: n = 28, PT: n = 26) and 49 patients the 12 months follow-up assessment (CT: n = 25, PT: n = 24). Primary study outcomes were memory and executive functioning composite scores. Mixed repeated measures ANOVAs, post-hoc t tests and multiple regression analyses were conducted.

resultsWe found a significant time x group interaction effect for the memory composite score (p = 0.006, η

conclusionsThis study provides Class 1 evidence that multidomain CT enhances memory functioning in PD-MCI after 6 months but not after 12 months, whereas executive functioning did not change in the long-term. CLINICAL

trial registrationGerman Clinical Trials Register (ID: DRKS00010186), 21.3.2016 (The study registration is outlined as retrospective due to an administrative delay. The first patient was enrolled three months after the registration process was started. A formal confirmation of this process from the German Clinical Trials Register can be obtained from the authors.).

Indexed as

Cognition DisordersCognitive DysfunctionParkinson DiseaseCognitionHumansNeuropsychological TestsRetrospective StudiesCognitionCognitive trainingLong-term effectsMild cognitive impairmentNon-pharmacological interventionParkinson’s disease

Identifiers

PMID33904966
PMCPMC8563628
OpenAlexW3157206499

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.