Evidence map›Paper›PMID 33904816›Full record

ArticleThe Journal of general virology2021

Oxidative stress specifically inhibits replication of dengue virus.

Naseem Ahmed Khan, Meenakshi Kar, Aleksha Panwar, Jigme Wangchuk, Saurabh Kumar, Asim Das, Anil Kumar Pandey, Rakesh Lodha, Guruprasad R Medigeshi

Open access · hybridAbstract read
In one paragraph

Article in The Journal of general virology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 37 citations in OpenAlex.

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  18. bioRxiv : the preprint server for biology · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Naseem Ahmed KhanClinical and Cellular Virology lab, Infection and Immunology, Translational Health Science and Technology Institute, Faridabad, Haryana, India.
Meenakshi KarClinical and Cellular Virology lab, Infection and Immunology, Translational Health Science and Technology Institute, Faridabad, Haryana, India.
Aleksha PanwarClinical and Cellular Virology lab, Infection and Immunology, Translational Health Science and Technology Institute, Faridabad, Haryana, India.
Jigme WangchukClinical and Cellular Virology lab, Infection and Immunology, Translational Health Science and Technology Institute, Faridabad, Haryana, India.
Saurabh KumarClinical and Cellular Virology lab, Infection and Immunology, Translational Health Science and Technology Institute, Faridabad, Haryana, India.
Asim DasEmployees State Insurance Corporation Medical College and Hospital, Faridabad, Haryana, India.
Anil Kumar PandeyEmployees State Insurance Corporation Medical College and Hospital, Faridabad, Haryana, India.
Rakesh LodhaDepartment of Pediatrics, All India Institute of Medical Sciences, New Delhi, India.
Guruprasad R MedigeshiClinical and Cellular Virology lab, Infection and Immunology, Translational Health Science and Technology Institute, Faridabad, Haryana, India.
Translational Health Science and Technology Institute · INEmployees' State Insurance Model Hospital · INAll India Institute of Medical Sciences · IN

Funding

DBT-Wellcome Trust India Alliance IA/S(I)/14/1/501291
6 · The paper itself

Abstract

Reactive oxygen species (ROS) are chemically active species which are involved in maintaining cellular and signalling processes at physiological concentrations. Therefore, cellular components that regulate redox balance are likely to play a crucial role in viral life-cycle either as promoters of viral replication or with antiviral functions. Zinc is an essential micronutrient associated with anti-oxidative systems and helps in maintaining a balanced cellular redox state. Here, we show that zinc chelation leads to induction of reactive oxygen species (ROS) in epithelial cells and addition of zinc restores ROS levels to basal state. Addition of ROS (H

Indexed as

Virus ReplicationAdolescentAedesAnimalsCaco-2 CellsChildChild, PreschoolChlorocebus aethiopsCricetinaeDengueDengue VirusHumansHydrogen PeroxideOxidative StressReactive Oxygen SpeciesRNA, ViralHydrogen PeroxideReactive Oxygen SpeciesRNA, ViralZincdengue virusHydrogen peroxideOxidative stressROSTPENxZinc

Identifiers

PMID33904816
PMCPMC7611606
OpenAlexW3157413445

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.