ArticleInternational journal of health policy and management2021
Cost-Effectiveness of Interventions to Improve Maternal, Newborn and Child Health Outcomes: A WHO-CHOICE Analysis for Eastern Sub-Saharan Africa and South-East Asia.
Article in International journal of health policy and management, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- The Impact of Antimicrobial Stewardship in Children in Low- and Middle-income Countries: A Systematic Review.The Pediatric infectious disease journal · 2022Pooled it
- Clear Waters, Bright Futures: Do Low-Cost Information Interventions Increase Health Preventive Behaviors.Health economics · 2025Trial
- Effect of maternal postnatal balanced energy protein supplementation and infant azithromycin on infant growth outcomes: an open-label randomized controlled trial.The American journal of clinical nutrition · 2024Trial
- Estimating the impact and cost-effectiveness of antenatal care approaches in 24 low- and middle-income countries: a modelling study.BMC global and public health · 2026Article
- Cost-effectiveness of maternal and neonatal health interventions in Ethiopia: a systematic review and meta-analysis.Health economics review · 2026Review
- The economic imperative of artificial intelligence in maternal and neonatal health: a review of evaluation benefits, frameworks, challenges, future perspectives, and limitations.Cost effectiveness and resource allocation : C/E · 2026Review
- Impact and cost-effectiveness of Neotree, a digital data capture and decision support tool designed to improve neonatal survival in Zimbabwe: an interrupted time series analysis and economic evaluation.BMJ global health · 2026Article
- Costs and cost-effectiveness of the Safer Births Bundle of Care intervention in Tanzania health facilities.PloS one · 2026Article
- Oral prophylaxis for the reduction of interdental dysbiosis-associated red complex pathogens during pregnancy: a randomized clinical trial.Frontiers in medicine · 2026Article
- Exploring attitudes toward fertility and childbearing among married women in Kabul, Afghanistan: a qualitative study.Reproductive health · 2025Article
- Monetary Valuation of Congenital Heart Disease in Indonesia: Economic Modeling Study.JMIR pediatrics and parenting · 2025Article
- Increasing postpartum family planning using an evidence-based approach: the success of a university teaching hospital in Rwanda.AJOG global reports · 2025Article
- Low-dose calcium supplementation during pregnancy in low and middle-income countries: A cost-effectiveness analysis.PLOS global public health · 2025Article
- Selecting Cost-Effectiveness Methods for Health Benefits Package Design: A Systematic Approach.International journal of health policy and management · 2025Article
- Cost-Effectiveness Analysis and Priority Setting in the Transition from Iron-Folic Acid (IFA) to Multiple Micronutrient Supplementation (MMS) for Pregnant Women in Indonesia.ClinicoEconomics and outcomes research : CEOR · 2025Article
- Well-Being and Healthcare Inequality on Bulon-Don Island in Southern Thailand-Results of a Pre-Intervention Field Survey.Children (Basel, Switzerland) · 2024Article
- International Newborn Screening: Where Are We in Saudi Arabia?Journal of epidemiology and global health · 2024Review
- Quantifying the Cost ofOpen forum infectious diseases · 2024Article
- Predictors of antenatal care services utilization by pregnant women in Afghanistan: Evidence from the Afghanistan Health Survey 2018.PloS one · 2024Article
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Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundInformation on cost-effectiveness allows policy-makers to evaluate if they are using currently available resources effectively and efficiently. Our objective is to examine the cost-effectiveness of health interventions to improve maternal, newborn and child health (MNCH) outcomes, to provide global evidence relative to the context of two geographic regions.
methodsWe consider interventions across the life course from adolescence to pregnancy and for children up to 5 years old. Interventions included are those that fall within the areas of immunization, child healthcare, nutrition, reproductive health, and maternal/newborn health, and for which it is possible to model impact on MNCH mortality outcomes using the Lives Saved Tool (LiST). Generalized cost-effectiveness analysis (GCEA) was used to derive average cost-effectiveness ratios (ACERs) for individual interventions and combinations (packages). Costs were assessed from the health system perspective and reported in international dollars. Health outcomes were estimated and reported as the gain in healthy life years (HLYs) due to the specific intervention or combination. The model was run for 2 regions: Eastern sub-Saharan Africa (SSA-E) and South-East Asia (SEA).
resultsThe World Health Organization (WHO) recommended interventions to improve MNCH are generally considered cost-effective, with the majority of interventions demonstrating ACERs below I$100/HLY saved in the chosen settings (low-and middle-income countries [LMICs]). Best performing interventions are consistent across the two regions, and include family planning, neonatal resuscitation, management of pneumonia and neonatal infection, vitamin A supplementation, and measles vaccine. ACERs below I$100 can be found across all delivery platforms, from community to hospital level. The combination of interventions into packages (such as antenatal care) produces favorable ACERs.
conclusionWithin each region there are interventions which represent very good value for money. There are opportunities to gear investments towards high-impact interventions and packages for MNCH outcomes. Cost-effectiveness tools can be used at national level to inform investment cases and overall priority setting processes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.