ArticlePhysiological reports2021
Reduced adiponectin levels in patients with COVID-19 acute respiratory failure: A case-control study.
Article in Physiological reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05449379 (Evaluation of Influence of Proprietary Physical Training Program on Quality of Life, Physical Endurance, Function of Muscles and Myokines Profile in Patients After COVID-19 Infection.), which is not on this map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluation of Influence of Proprietary Physical Training Program on Quality of Life, Physical Endurance, Function of Muscles and Myokines Profile in Patients After COVID-19 Infection.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Organokines in COVID-19: A Systematic Review.Cells · 2023Pooled it
- Effect of obesity on the acute response to SARS-CoV-2 infection and development of post-acute sequelae of COVID-19 (PASC) in nonhuman primates.PLoS pathogens · 2025Article
- Correlation between blood cell indices and adiponectin and leptin levels in COVID-19.Biomolecules & biomedicine · 2025Article
- Serum Adiponectin Predicts COVID-19 Severity.Biomedicines · 2024Article
- Are adipokines related to COVID-19 and its severity? A systematic review and meta-analysis.Medicine and pharmacy reports · 2024Review
- Diabetes Mellitus, Energy Metabolism, and COVID-19.Endocrine reviews · 2024Review
- Circulating levels of adiponectin and AdipoR expression in peripheral blood mononuclear cells are associated with lower respiratory tract Infection.Frontiers in immunology · 2024Article
- Exploring the Network between Adipocytokines and Inflammatory Response in SARS-CoV-2 Infection: A Scoping Review.Nutrients · 2023Article
- Review
- Clinical Disease Characteristics and Treatment Trajectories Associated with Mortality among COVID-19 Patients in Punjab, Pakistan.Healthcare (Basel, Switzerland) · 2023Article
- Pulmonary recovery from COVID-19 in patients with metabolic diseases: a longitudinal prospective cohort study.Scientific reports · 2023Article
- Adiponectin, Leptin, and Resistin Are Dysregulated in Patients Infected by SARS-CoV-2.International journal of molecular sciences · 2023Article
- Regulation of lung inflammation by adiponectin.Frontiers in immunology · 2023Review
- Sex differences in predictive factors for onset of type 2 diabetes in Japanese individuals: A 15-year follow-up study.Journal of diabetes investigation · 2023Article
- Circulating Adiponectin Levels Are Inversely Associated with Mortality and Respiratory Failure in Patients Hospitalized with COVID-19.International journal of endocrinology · 2023Article
- The potential molecular implications of adiponectin in the evolution of SARS-CoV-2: Inbuilt tendency.Journal of King Saud University. Science · 2022Review
- Chemerin as a Potential Marker of Resolution of Inflammation in COVID-19 Infection.Biomedicines · 2022Article
- SARS-CoV-2 variant spike and accessory gene mutations alter pathogenesis.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- SARS-CoV-2 Variant Spike and accessory gene mutations alter pathogenesis.bioRxiv : the preprint server for biology · 2022Article
- A SURGE OF TYPE 1 DIABETES MELLITUS AMONG NIGERIAN CHILDREN DURING THE COVID-19 PANDEMIC.Annals of Ibadan postgraduate medicine · 2022Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Hypoadiponectinemia is speculated to play a key role in the relationship between obesity and COVID-19 respiratory failure. However, only one study has examined adiponectin levels in COVID-19 patients, and none have investigated adiponectin levels strictly in patients with acute respiratory failure. In this study, we performed a retrospective case-control study of adipokine levels in patients with acute respiratory failure caused by either COVID-19 or other viral/bacterial source. All patients with COVID-19 respiratory failure in the University of Virginia Biorepository and Tissue Research database were included. We also selected patients with non-COVID-19 infectious respiratory failure from the same biorepository to serve as a comparison cohort. Plasma adipokine levels were measured on three occasions during the first 72 hours of hospitalization. Twelve patients with COVID-19 respiratory failure and 17 patients with other infectious respiratory failure were studied. Adiponectin levels were significantly lower in patients with COVID-19 respiratory failure, even after adjustment for age, sex, BMI, and other covariates. In conclusion, adiponectin levels appear to be reduced in COVID-19 respiratory failure. Larger studies are needed to confirm this report.
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