Evidence map›Paper›PMID 33904638›Full record

ArticleCatheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions2021

Patients with COVID-19 who experience a myocardial infarction have complex coronary morphology and high in-hospital mortality: Primary results of a nationwide angiographic study.

Alexandre Abizaid, Carlos M Campos, Patrícia O Guimarães, José de Ribamar Costa, Breno A A Falcão, Fernanda Mangione, Adriano Caixeta, Pedro A Lemos, Fabio S de Brito, Ricardo Cavalcante and 13 more

Abstract readMulticenter Study
In one paragraph

Article in Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. Review
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  9. Review
  10. Patients with COVID-19 who experience a myocardial infarction have complex coronary morphology and high in-hospital mortality: Primary results of a nationwide angiographic study.Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions · 2021
    Article
  11. Article
  12. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Alexandre AbizaidHeart Institute, InCor, University of Sao Paulo Medical School, Sao Paulo, Brazil.
Carlos M CamposHeart Institute, InCor, University of Sao Paulo Medical School, Sao Paulo, Brazil.ORCID 0000-0003-1734-6924
Patrícia O GuimarãesHeart Institute, InCor, University of Sao Paulo Medical School, Sao Paulo, Brazil.ORCID 0000-0002-0626-2250
José de Ribamar CostaHospital do Coração (HCor), São Paulo, Brazil.
Breno A A FalcãoDepartment of Cardiology, Hospital de Messejana, Fortaleza, Brazil.
Fernanda MangioneDepartment of Cardiology, Hospital Beneficência Portuguesa, Sao Paulo, Brazil.ORCID 0000-0002-8212-1732
Adriano CaixetaEscola Paulista de Medicina, Universidade Federal de Sao Paulo, Sao Paulo, Brazil.
Pedro A LemosDepartment of Cardiology, Hospital Israelita Albert Einstein, Sao Paulo, Brazil.
Fabio S de BritoHeart Institute, InCor, University of Sao Paulo Medical School, Sao Paulo, Brazil.
Ricardo CavalcanteDepartment of Cardiology, Hospital São Camilo, Sao Paulo, Brazil.
Cristiano Guedes BezerraDepartment of Cardiology, Hospital Ana Nery, Salvador, Brazil.ORCID 0000-0002-4762-0579
Leandro CortesDepartment of Cardiology, Instituto Nacional de Cardiologia, Rio de Janeiro, Brazil.
Henrique B RibeiroDepartment of Cardiology, Hospital Samaritano Paulista, Sao Paulo, Brazil.
Francis R de SouzaHeart Institute, InCor, University of Sao Paulo Medical School, Sao Paulo, Brazil.
Natassja HuemerHeart Institute, InCor, University of Sao Paulo Medical School, Sao Paulo, Brazil.
Renata M do ValHeart Institute, InCor, University of Sao Paulo Medical School, Sao Paulo, Brazil.
Bruno CaramelliHeart Institute, InCor, University of Sao Paulo Medical School, Sao Paulo, Brazil.
Daniela CalderaroHeart Institute, InCor, University of Sao Paulo Medical School, Sao Paulo, Brazil.
Felipe G LimaHeart Institute, InCor, University of Sao Paulo Medical School, Sao Paulo, Brazil.
Ludhmila A HajjarHeart Institute, InCor, University of Sao Paulo Medical School, Sao Paulo, Brazil.
Roxana MehranThe Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.ORCID 0000-0002-5546-262X
Roberto Kalil FilhoHeart Institute, InCor, University of Sao Paulo Medical School, Sao Paulo, Brazil.
COVID MI investigators

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesWe aimed to explore angiographic patterns and in-hospital outcomes of patients with concomitant coronavirus disease-19 (COVID-19) and myocardial infarction (MI).

backgroundPatients with COVID-19 may experience MI during the course of the viral infection. However, this association is currently poorly understood.

methodsThis is a multicenter prospective study of consecutive patients with concomitant COVID-19 and MI who underwent coronary angiography. Quantitative and qualitative coronary angiography were analyzed by two observers in an independent core lab.

resultsA total of 152 patients were included, of whom 142 (93.4%) had COVID-19 diagnosis confirmation. The median time between symptom onset and hospital admission was 5 (1-10) days. A total of 83 (54.6%) patients presented with ST-elevation MI. The median angiographic Syntax score was 16 (9.0-25.3) and 69.0% had multi-vessel disease. At least one complex lesion was found in 73.0% of patients, 51.3% had a thrombus containing lesion, and 57.9% had myocardial blush grades 0/1. The overall in-hospital mortality was 23.7%. ST-segment elevation MI presentation and baseline myocardial blush grades 0 or 1 were independently associated with a higher risk of death (HR 2.75, 95%CI 1.30-5.80 and HR 3.73, 95%CI 1.61-8.61, respectively).

conclusionsPatients who have a MI in the context of ongoing COVID-19 mostly present complex coronary morphologies, implying a background of prior atherosclerotic disease superimposed on a thrombotic milieu. The in-hospital prognosis is poor with a markedly high mortality, prompting further investigation to better clarify this newly described condition.

Indexed as

COVID-19Myocardial InfarctionPercutaneous Coronary InterventionCoronary AngiographyCOVID-19 TestingHospital MortalityHumansProspective StudiesSARS-CoV-2Treatment Outcomecoronary angiographycoronavirus disease 2019myocardial infarction

Identifiers

PMID33904638
PMCPMC8239511

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.