ArticleeLife2021
Constructing an adult orofacial premotor atlas in Allen mouse CCF.
Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- A projection atlas of excitatory and inhibitory inputs to the preBötzinger complex: substrates for multimodal breathing control.Journal of neurophysiology · 2026Article
- Theory and evidence of amplitude control by frequency detuning in a coupled neuronal oscillator system.PLoS computational biology · 2026Article
- Brainstem Circuits for Rhythm Generation and Coordination of Orofacial Movements.Annual review of neuroscience · 2026Review
- The rewarding crunch: A brainstem circuit links incisor mechanosensation to motivated gnawing.Neuron · 2026Article
- Cheese3D enables sensitive detection and analysis of whole-face movement in mice.Nature neuroscience · 2026Article
- A genetically defined pontine nucleus essential for ingestion in mice.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- A brainstem map of orofacial rhythms.bioRxiv : the preprint server for biology · 2025Article
- Rescue-like behavior in a bystander mouse toward anesthetized conspecifics promotes arousal via a tongue-brain connection.Science advances · 2025Article
- General anesthesia activates a central anxiolytic center in the BNST.Cell reports · 2024Article
- Monosynaptic Inputs to Ventral Tegmental Area Glutamate and GABA Co-transmitting Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
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- Reverse-engineering placebo analgesia.Current biology : CB · 2024Article
- Where Top-Down Meets Bottom-Up: Cell-Type Specific Connectivity Map of the Whisker System.Neuroinformatics · 2024Article
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- Theory of hierarchically organized neuronal oscillator dynamics that mediate rodent rhythmic whisking.Neuron · 2022Article
- Fentanyl effects on respiratory neuron activity in the dorsolateral pons.Journal of neurophysiology · 2022Article
- MS and GTO proprioceptor subtypes in the molecular genetic era: Opportunities for new advances and perspectives.Current opinion in neurobiology · 2022Review
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Premotor circuits in the brainstem project to pools of orofacial motoneurons to execute essential motor action such as licking, chewing, breathing, and in rodent, whisking. Previous transsynaptic tracing studies only mapped orofacial premotor circuits in neonatal mice, but the adult circuits remain unknown as a consequence of technical difficulties. Here, we developed a three-step monosynaptic transsynaptic tracing strategy to identify premotor neurons controlling vibrissa, tongue protrusion, and jaw-closing muscles in the adult mouse. We registered these different groups of premotor neurons onto the Allen mouse brain common coordinate framework (CCF) and consequently generated a combined 3D orofacial premotor atlas, revealing unique spatial organizations of distinct premotor circuits. We further uncovered premotor neurons that simultaneously innervate multiple motor nuclei and, consequently, are likely to coordinate different muscles involved in the same orofacial motor actions. Our method for tracing adult premotor circuits and registering to Allen CCF is generally applicable and should facilitate the investigations of motor controls of diverse behaviors.
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