Evidence map›Paper›PMID 33904404›Full record

ArticleeLife2021

Protomer alignment modulates specificity of RNA substrate recognition by Ire1.

Weihan Li, Kelly Crotty, Diego Garrido Ruiz, Mark Voorhies, Carlos Rivera, Anita Sil, R Dyche Mullins, Matthew P Jacobson, Jirka Peschek, Peter Walter

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Evolutionary Aspects of the Unfolded Protein Response.Cold Spring Harbor perspectives in biology · 2022
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Weihan Li *Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, United States.ORCID 0000-0003-4718-1884
Kelly Crotty *Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, United States.
Diego Garrido RuizDepartment of Pharmaceutical Chemistry, University of California at San Francisco, San Francisco, United States.ORCID 0000-0002-2441-385X
Mark VoorhiesDepartment of Microbiology and Immunology, University of California at San Francisco, San Francisco, United States.ORCID 0000-0001-8815-7384
Carlos RiveraDepartment of Molecular Biophysics and Biochemistry, Yale School of Medicine, New Haven, United States.
Anita SilDepartment of Microbiology and Immunology, University of California at San Francisco, San Francisco, United States.
R Dyche MullinsHoward Hughes Medical Institute, San Francisco, United States.
Matthew P JacobsonDepartment of Pharmaceutical Chemistry, University of California at San Francisco, San Francisco, United States.
Jirka PeschekDepartment of Biochemistry and Biophysics, University of California San Francisco, San Francisco, United States.ORCID 0000-0001-8158-9301
Peter WalterDepartment of Biochemistry and Biophysics, University of California San Francisco, San Francisco, United States.ORCID 0000-0002-6849-708X
Howard Hughes Medical Institute · USUniversity of California, San Francisco · USAlbert Einstein College of Medicine · USYale University · US

Funding

MECHANISM OF PROTEIN TRANSLOCATION ACROSS MEMBRANESR01GM032384 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI STROUD, ROBERT M · 1985 to 2023
$7.6M
Assembly and function of cytoskeletal systems in eukaryotic and prokaryoticcellsR35GM118119 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MULLINS, R DYCHE · 2016 to 2025
$4.8M
Gene circuits that control morphology in HistoplasmaR37AI066224 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Anita Sil · 2020 to 2026
$3.3M
MECHANISM OF PROTEIN TRANSLOCATION ACROSS MEMBRANESR37GM032384 · NIGMS · UNIVERSITY OF CALIFORNIA SAN FRANCISCO · PI WALTER, PETER · 1993 to 2002
$907k
Howard Hughes Medical InstituteNIAID NIH HHS R37 AI066224NIGMS NIH HHS R01 GM032384NIGMS NIH HHS R35 GM118119NIGMS NIH HHS R37 GM032384
6 · The paper itself

Abstract

The unfolded protein response (UPR) maintains protein folding homeostasis in the endoplasmic reticulum (ER). In metazoan cells, the Ire1 branch of the UPR initiates two functional outputs-non-conventional mRNA splicing and selective mRNA decay (RIDD). By contrast, Ire1 orthologs from

Indexed as

Membrane GlycoproteinsMolecular Dynamics SimulationPhylogenyProtein Serine-Threonine KinasesProtein SubunitsRibonucleasesRNARNA SplicingSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsSchizosaccharomycesSequence AlignmentSubstrate SpecificityIRE1 protein, S cerevisiaeMembrane GlycoproteinsProtein Serine-Threonine KinasesProtein SubunitsRibonucleasesRNASaccharomyces cerevisiae Proteinsbiochemistrychemical biologyenzymatic substrate specificityIre1RNA biologyS. cerevisiaeS. pombeunfolded protein response

Identifiers

PMID33904404
PMCPMC8104961
OpenAlexW3159113186

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.