Evidence map›Paper›PMID 33904393›Full record

ArticleeLife2021

Toxoplasma TgATG9 is critical for autophagy and long-term persistence in tissue cysts.

David Smith, Geetha Kannan, Isabelle Coppens, Fengrong Wang, Hoa Mai Nguyen, Aude Cerutti, Einar B Olafsson, Patrick A Rimple, Tracey L Schultz, Nayanna M Mercado Soto and 3 more

Open access · goldAbstract read
In one paragraph

Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
6.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 51 citations in OpenAlex.

  1. Article
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  4. bioRxiv : the preprint server for biology · 2026
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  8. mSphere · 2025
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  14. AmSphere · 2024
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  15. Article
  16. The apicoplast is important for the viability and persistence ofProceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  17. Article
  18. Article
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 4 countries.

David SmithDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, United States.ORCID 0000-0002-5158-0522
Geetha KannanDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, United States.
Isabelle CoppensDepartment of Molecular Microbiology and Immunology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, United States.
Fengrong WangDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, United States.
Hoa Mai NguyenLaboratory of PathogenHost Interactions, UMR 5235, CNRS, Université de Montpellier, Montpellier, France.
Aude CeruttiLaboratory of PathogenHost Interactions, UMR 5235, CNRS, Université de Montpellier, Montpellier, France.
Einar B OlafssonDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, United States.
Patrick A RimpleDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, United States.
Tracey L SchultzDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, United States.
Nayanna M Mercado SotoDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, United States.
Manlio Di CristinaDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, United States.ORCID 0000-0003-4154-5210
Sébastien BesteiroLaboratory of PathogenHost Interactions, UMR 5235, CNRS, Université de Montpellier, Montpellier, France.ORCID 0000-0003-1853-1494
Vern B CarruthersDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, United States.
University of Michigan · USCentre National de la Recherche Scientifique · FRJohns Hopkins University · USUniversity of Perugia · ITWaterNSW · AU

Funding

RESEARCH TRAINING IN EXPERIMENTAL IMMUNOPATHOLOGYT32AI007413 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Bethany B. Moore · 1993 to 2026
$9.8M
University of Michigan Postbaccalaureate Research Education Program (UM PREP)R25GM086262 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ALLEN, BENJAMIN · 2009 to 2024
$6.1M
Targeting of host vesicles to the vacuole of Toxoplasma and lipid cargo sortingR01AI060767 · NIAID · JOHNS HOPKINS UNIVERSITY · PI COPPENS, ISABELLE · 2004 to 2020
$5.1M
Parasite autophagy as a key survival mechanism for the AIDS-associated pathogen Toxoplasma gondiiR01AI120607 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CARRUTHERS, VERNON BRUCE · 2016 to 2025
$4.0M
NIAID NIH HHS R01 AI060767NIAID NIH HHS R01 AI120607NIAID NIH HHS T32 AI007413NIGMS NIH HHS R25 GM086262
6 · The paper itself

Abstract

Many of the world's warm-blooded species are chronically infected with

Indexed as

AutophagyAnimalsBrainCell LineDisease Models, AnimalFemaleHost-Parasite InteractionsHumansLife Cycle StagesMembrane ProteinsMiceMice, Inbred CBAMitochondriaProtozoan ProteinsTime FactorsToxoplasmaATG9 protein, Toxoplasma gondiiMembrane ProteinsProtozoan ProteinsapicomplexaATG9chronic infectioninfectious diseasemicrobiologyparasiteprotozoanToxoplasma gondii

Identifiers

PMID33904393
PMCPMC8128441
OpenAlexW3158111691

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.