Evidence map›Paper›PMID 33904261›Full record

ArticleJournal of Korean medical science2021

Revised Korean Antiviral Guideline Reduces the Hepatitis B-related Hepatocellular Carcinoma Risk in Cirrhotic Patients.

David Sooik Kim, Soo Young Park, Beom Kyung Kim, Jun Yong Park, Do Young Kim, Kwang Hyub Han, Yu Rim Lee, Won Young Tak, Young Oh Kweon, Inkyung Jung and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Korean medical science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

David Sooik Kim *Department of Internal Medicine, Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0001-6433-2176
Soo Young Park *Department of Internal Medicine, Kyungpook National University Hospital, Daegu, Korea.ORCID https://orcid.org/0000-0001-6796-4929
Beom Kyung KimDepartment of Internal Medicine, Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0002-5363-2496
Jun Yong ParkDepartment of Internal Medicine, Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0001-6324-2224
Do Young KimDepartment of Internal Medicine, Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0002-8327-3439
Kwang Hyub HanDepartment of Internal Medicine, Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0003-3960-6539
Yu Rim LeeDepartment of Internal Medicine, Kyungpook National University Hospital, Daegu, Korea.ORCID https://orcid.org/0000-0001-5711-3928
Won Young TakDepartment of Internal Medicine, Kyungpook National University Hospital, Daegu, Korea.ORCID https://orcid.org/0000-0002-1914-5141
Young Oh KweonDepartment of Internal Medicine, Kyungpook National University Hospital, Daegu, Korea.ORCID https://orcid.org/0000-0001-5708-7985
Inkyung JungDivision of Biostatistics, Department of Biomedical Systems Informatics, Yonsei University College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0003-3780-3213
Minkyung HanBiostatistics Collaboration Unit, Department of Biomedical Systems Informatics, Yonsei University College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0002-5011-5557
Eun Hwa KimBiostatistics Collaboration Unit, Department of Biomedical Systems Informatics, Yonsei University College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0003-1692-6126
Sang Hoon AhnDepartment of Internal Medicine, Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0002-3629-4624
Seung Up KimDepartment of Internal Medicine, Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0002-9658-8050
Yonsei University · KRKyungpook National University Hospital · KR

Funding

National Research Foundation of Korea 2019R1A2C4070136Yonsei University College of Medicine
6 · The paper itself

Abstract

backgroundSince September 2015, the initiation of antiviral therapy (AVT) for patients with chronic hepatitis B (CHB)-related cirrhosis has been reimbursed according to the revised Korean Association for the Study of Liver (KASL) guideline, if the patient had hepatitis B virus DNA level ≥ 2,000 IU/L, regardless of aminotransferase or alanine aminotransferase levels. This study investigated whether the KASL guideline implementation reduced the risk of CHB-related hepatocellular carcinoma (HCC) in patients with cirrhosis in South Korea.

methodsA total of 429 patients with CHB-related cirrhosis who initiated AVT between 2014 and 2016 were recruited. The risk of HCC development was compared between patients who initiated AVT before and after September 2015 (pre-guideline [n = 196, 45.7%] vs. post-guideline implementation [n = 233, 54.3%]).

resultsUnivariate analysis showed that AVT initiation before guideline implementation, older age, male gender, and diabetes significantly predicted increased risk of HCC development (all

conclusionThe prognosis of patients with CHB-related cirrhosis who initiated AVT improved after guideline implementation according to the revised KASL guideline.

Indexed as

Guidelines as TopicAntiviral AgentsCarcinoma, HepatocellularFemaleHepatitis B, ChronicHepatitis B virusHumansIncidenceLiver CirrhosisLiver NeoplasmsMaleMiddle AgedRepublic of KoreaRisk FactorsTreatment OutcomeAntiviral AgentsAntiviral TherapyGuidelineHepatitis BHepatocellular CarcinomaManagement

Identifiers

PMID33904261
PMCPMC8076846
OpenAlexW3141473097

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.