Evidence map›Paper›PMID 33904010›Full record

ArticleJournal of assisted reproduction and genetics2021

Deep learning early warning system for embryo culture conditions and embryologist performance in the ART laboratory.

Charles L Bormann, Carol Lynn Curchoe, Prudhvi Thirumalaraju, Manoj K Kanakasabapathy, Raghav Gupta, Rohan Pooniwala, Hemanth Kandula, Irene Souter, Irene Dimitriadis, Hadi Shafiee

Erratum issuedAbstract read
In one paragraph

Article in Journal of assisted reproduction and genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Article
  2. Article
  3. Key Performance Indicators Applied in Medicine.International archives of otorhinolaryngology · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Proceedings of the first world conference on AI in fertility.Journal of assisted reproduction and genetics · 2023
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Artificial intelligence-the future is now.Journal of assisted reproduction and genetics · 2021
    Article
  18. Review
  19. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Charles L BormannMassachusetts General Hospital Fertility Center, Obstetrics/Gynecology/Reproductive Endocrinology and Infertility, Boston, MA, USA.
Carol Lynn CurchoeColorado Center for Reproductive Medicine, Newport Beach, CA, USA. cburton@fertilitylabsciences.com.ORCID http://orcid.org/0000-0002-7534-5906
Prudhvi ThirumalarajuDivision of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Manoj K KanakasabapathyDivision of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Raghav GuptaDivision of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Rohan PooniwalaDivision of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Hemanth KandulaDivision of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Irene SouterMassachusetts General Hospital Fertility Center, Obstetrics/Gynecology/Reproductive Endocrinology and Infertility, Boston, MA, USA.
Irene DimitriadisMassachusetts General Hospital Fertility Center, Obstetrics/Gynecology/Reproductive Endocrinology and Infertility, Boston, MA, USA.
Hadi ShafieeDivision of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Staff competency is a crucial component of the in vitro fertilization (IVF) laboratory quality management system because it impacts clinical outcomes and informs the key performance indicators (KPIs) used to continuously monitor and assess culture conditions. Contemporary quality control and assurance in the IVF lab can be automated (collect, store, retrieve, and analyze), to elevate quality control and assurance beyond the cursory monthly review. Here we demonstrate that statistical KPI monitoring systems for individual embryologist performance and culture conditions can be detected by artificial intelligence systems to provide systemic, early detection of adverse outcomes, and identify clinically relevant shifts in pregnancy rates, providing critical validation for two statistical process controls proposed in the Vienna Consensus Document; intracytoplasmic sperm injection (ICSI) fertilization rate and day 3 embryo quality.

Indexed as

Deep LearningEarly Warning ScoreLaboratory PersonnelBlastocystEmbryo Culture TechniquesEmbryonic DevelopmentFemaleHumansImage Processing, Computer-AssistedNeural Networks, ComputerPregnancyPregnancy RateSperm Injections, IntracytoplasmicAIAssisted reproductive technologiesClinical decision-makingCNNCompetencyConvolutional neural networkEmbryologyEmbryo qualityInfertility, Artificial intelligenceLaboratory quality management systemsProficiencyQuality assurance

Identifiers

PMID33904010
PMCPMC8324654

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.