ArticleJournal of assisted reproduction and genetics2021
Utilization of preimplantation genetic testing in the USA.
Article in Journal of assisted reproduction and genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- Preimplantation genetic testing and disorders of placental implantation: a systematic review and meta-analysis.Journal of assisted reproduction and genetics · 2025Pooled it
- Effect of re-biopsy and re-vitrification on clinical outcomes in preimplantation genetic testing for aneuploidy.Journal of assisted reproduction and genetics · 2025Article
- Article
- Impact of PGT Introduction on IVF Laboratory Workload: Lessons Learned from a Single-Center Experience of 5258 Biopsies over a 10-Year Period.Life (Basel, Switzerland) · 2025Article
- Pediatric predictive testing to inform preimplantation genetic testing: A case report and review of the literature.Journal of genetic counseling · 2025Review
- United States racial/ethnic disparities in PGT-A use: an analysis of 2014-2020 SART CORS database.Reproductive biology and endocrinology : RB&E · 2025Article
- PGT-A: what's it for, what's wrong?Journal of assisted reproduction and genetics · 2025Article
- Review
- Clinical-grade whole genome sequencing-based haplarithmisis enables all forms of preimplantation genetic testing.Nature communications · 2024Article
- One size does not fit all: the personal nature of completed embryo donation.Journal of assisted reproduction and genetics · 2024Article
- Effect of time post warming to embryo transfer on human blastocyst metabolism and pregnancy outcome.Journal of assisted reproduction and genetics · 2024Article
- Patient interest in and clinician reservations on polygenic embryo screening: a qualitative study of stakeholder perspectives.Journal of assisted reproduction and genetics · 2024Article
- Public Attitudes, Interests, and Concerns Regarding Polygenic Embryo Screening.JAMA network open · 2024Article
- Evaluation of pre-implantation genetic testing for aneuploidy outcomes in patients without infertility undergoing in vitro fertilization compared to infertile controls.Journal of assisted reproduction and genetics · 2023Article
- Divergence Between Clinician and Patient Perspectives on Polygenic Embryo Screening: A Qualitative Study.medRxiv : the preprint server for health sciences · 2023Article
- PGT-A: Houston, we have a problem.Journal of assisted reproduction and genetics · 2023Article
- Predicted probabilities of live birth following assisted reproductive technology using United States national surveillance data from 2016 to 2018.American journal of obstetrics and gynecology · 2023Article
- Aneuploidy screening after preimplantation genetic testing: a national survey of physician knowledge and practice.Journal of assisted reproduction and genetics · 2023Article
- Fresh vs. frozen embryo transfer: new approach to minimize the limitations of using national surveillance data for clinical research.Fertility and sterility · 2023Article
- Preimplantation genetic testing for aneuploidy: challenges in clinical practice.Human genomics · 2022Review
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo evaluate the use of preimplantation genetic testing (PGT) and live birth rates (LBR) in the USA from 2014 to 2017 and to understand how PGT is being used at a clinic and state level.
methodsThis study accessed SART data for 2014 to 2017 to determine LBR and the CDC for years 2016 and 2017 to identify PGT usage. Primary cycles included only the first embryo transfer within 1 year of an oocyte retrieval; subsequent cycles included transfers occurring after the first transfer or beyond 1 year of oocyte retrieval.
resultsIn the SART data, the number of primary PGT cycles showed a significant monotonic annual increase from 18,805 in 2014 to 54,442 in 2017 (P = 0.042) and subsequent PGT cycles in these years increased from 2946 to 14,361 (P = 0.01). There was a significant difference in primary PGT cycle use by age, where younger women had a greater percentage of PGT treatment cycles than older women. In both PGT and non-PGT cycles, the LBR per oocyte retrieval decreased significantly from 2014 to 2017 (P<0001) and younger women had a significantly higher LBR per oocyte retrieval compared to older women (P < 0.001). The CDC data revealed that in 2016, just 53 (11.4%) clinics used PGT for more than 50% of their cycles, which increased to 99 (21.4%) clinics in 2017 (P< 0.001).
conclusionsA growing number of US clinics are offering PGT to their patients. These findings support re-evaluation of the application for PGT.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.