ReviewMucosal immunology2021
Maternal natural killer cells at the intersection between reproduction and mucosal immunity.
Review in Mucosal immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Number and function of uterine natural killer cells in recurrent miscarriage and implantation failure: a systematic review and meta-analysis.Human reproduction update · 2022Pooled it
- Immunology of pregnancy and sepsis: shared and specific pathways guiding future precision care.EBioMedicine · 2026Review
- Single-cell insights into trophoblast heterogeneity and adaptive dysfunction in selective fetal growth restriction.Communications biology · 2026Article
- Implantation Failure: Where to Look Up?Journal of clinical medicine · 2025Review
- Female ILCs on the spotlight.Nature immunology · 2025Article
- Targeting Decidual CD16Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Gestational diabetes augments group B Streptococcus infection by disrupting maternal immunity and the vaginal microbiota.Nature communications · 2024Article
- Recurrent reproductive failure and celiac genetic susceptibility, a leading role of gluten.Frontiers in immunology · 2024Article
- Maternal gut microbiota in the health of mothers and offspring: from the perspective of immunology.Frontiers in immunology · 2024Review
- The impact of SARS-COV-2 infection on menstruation.BMC women's health · 2023Article
- Balance between maternal antiviral response and placental transfer of protection in gestational SARS-CoV-2 infection.JCI insight · 2023Article
- Regulatory T cell adoptive transfer alters uterine immune populations, increasing a novel MHC-IIFrontiers in immunology · 2023Article
- Review
- Overexpression of ERAP2N in Human Trophoblast Cells Promotes Cell Death.International journal of molecular sciences · 2021Article
- Immunoendocrine Dysregulation during Gestational Diabetes Mellitus: The Central Role of the Placenta.International journal of molecular sciences · 2021Review
- Optimizing Maternal Microbiome: Role in Improved Conception and Pregnancy Outcome.Reproductive medicine and biologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Many maternal immune cells populate the decidua, which is the mucosal lining of the uterus transformed during pregnancy. Here, abundant natural killer (NK) cells and macrophages help the uterine vasculature adapt to fetal demands for gas and nutrients, thereby supporting fetal growth. Fetal trophoblast cells budding off the forming placenta and invading deep into maternal tissues come into contact with these and other immune cells. Besides their homeostatic functions, decidual NK cells can respond to pathogens during infection, but in doing so, they may become conflicted between destroying the invader and sustaining fetoplacental growth. We review how maternal NK cells balance their double duty both in the local microenvironment of the uterus and systemically, during toxoplasmosis, influenza, cytomegalovirus, malaria and other infections that threat pregnancy. We also discuss recent developments in the understanding of NK-cell responses to SARS-Cov-2 infection and the possible dangers of COVID-19 during pregnancy.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.