ArticleScientific reports2021
Possible burden of hyperuricaemia on mortality in a community-based population: a large-scale cohort study.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- The Effect of Hyperuricemia on Cognitive Impairment: A Cohort Study and Systematic Review.Nutrients · 2026Pooled it
- Long-term cardiovascular mortality risk of hyperuricemia and chronic kidney disease in a general Japanese population: NIPPON DATA90.Endocrine · 2026Article
- Inflammation mediates the association between hyperuricemia and stroke mortality: a cohort study.Frontiers in neurology · 2025Article
- Sex-specific associations between blood urea nitrogen and risk of hyperuricemia in U.S. adults: the NHANES 1999-2020.Frontiers in endocrinology · 2025Article
- The Association of Dietary Diversity with Hyperuricemia among Community Inhabitants in Shanghai, China: A Prospective Research.Nutrients · 2024Article
- Cigarette smoking and progression of kidney dysfunction: a longitudinal cohort study.Clinical and experimental nephrology · 2024Article
- Ethanol Extracts fromFoods (Basel, Switzerland) · 2024Article
- Dyslipidemia and hyperuricemia: a cross-sectional study of residents in Wuhu, China.BMC endocrine disorders · 2024Article
- Interaction between anemia and hyperuricemia in the risk of all-cause mortality in patients with chronic kidney disease.Frontiers in endocrinology · 2024Article
- Prevalence and influencing factors of hyperuricemia in middle-aged and older adults in the Yao minority area of China: a cross-sectional study.Scientific reports · 2023Article
- Concentration of serum uric acid in patients with Renal Artery Stenosis and Hypertension prEdict Future nephropathy and death: C-RASHEF study.Journal of clinical hypertension (Greenwich, Conn.) · 2023Article
- Serum uric acid to creatinine ratio is a useful predictor of all-cause mortality among hypertensive patients.Clinical hypertension · 2023Article
- Epidemiology and treatment-related concerns of gout and hyperuricemia in Korean.Journal of rheumatic diseases · 2023Review
- Interactive effect of serum uric acid and handgrip strength on all-cause mortality among Japanese community-dwelling people.Metabolism open · 2023Article
- Adherence to DASH Dietary Pattern and Its Association with Incident Hyperuricemia Risk: A Prospective Study in Chinese Community Residents.Nutrients · 2022Article
- Association of Visceral Fat Area and Hyperuricemia in Non-Obese US Adults: A Cross-Sectional Study.Nutrients · 2022Article
- Serum and urine uric acid level may have different predictive value for urinary stone composition: a retrospective cohort study of 718 patients in Chinese population.International urology and nephrology · 2022Article
- Hyperuricemia is associated with all-cause mortality among males and females: Findings from a study on Japanese community-dwelling individuals.Metabolism open · 2022Article
- The Impact of an Elevated Uric Acid Level on the Prevalence of Coronary Artery Disease in Pancreas Transplant Candidates with Type 1 Diabetes: A Cross Sectional Study.Journal of clinical medicine · 2022Article
- Prevalence of hyperuricemia and the population attributable fraction of modifiable risk factors: Evidence from a general population cohort in China.Frontiers in public health · 2022Article
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Authors and funding
14 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hyperuricaemia is a risk for premature death. This study evaluated the burden of hyperuricaemia (serum urate > 7 mg/dL) for all-cause and cardiovascular mortality in 515,979 health checkup participants using an index of population attributable fraction (PAF). Prevalence of hyperuricaemia at baseline was 10.8% in total subjects (21.8% for men and 2.5% for women). During 9-year follow-up, 5952 deaths were noted, including 1164 cardiovascular deaths. In the Cox proportional hazard analysis adjusted for confounding factors, hyperuricaemia was independently associated with all-cause and cardiovascular mortality (adjusted hazard ratios [95% confidence interval]; 1.36 [1.25-1.49] and 1.69 [1.41-2.01], respectively). Adjusted PAFs of hyperuricaemia for all-cause and cardiovascular deaths were 2.9% and 4.4% (approximately 1 in 34 all-cause deaths and 1 in 23 cardiovascular deaths), respectively. In the subgroup analysis, the association between hyperuricaemia and death was stronger in men, smokers, and subjects with renal insufficiency. Adjusted PAFs for all-cause and cardiovascular deaths were 5.3% and 8.1% in men; 5.8% and 7.5% in smokers; and 5.5% and 7.3% in subjects with renal insufficiency. These results disclosed that a substantial number of all-cause and cardiovascular deaths were statistically relevant to hyperuricaemia in the community-based population, especially men, smokers, and subjects with renal insufficiency.
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