Evidence map›Paper›PMID 33903664›Full record

Trial reportScientific reports2021

Cumulative risks of colorectal cancer in Han Chinese patients with Lynch syndrome in Taiwan.

Abram Bunya Kamiza, Wen-Chang Wang, Jeng-Fu You, Reiping Tang, Huei-Tzu Chien, Chih-Hsiung Lai, Li-Ling Chiu, Tsai-Ping Lo, Kuan-Yi Hung, Chao A Hsiung and 1 more

Open access · goldAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 1 country.

Abram Bunya Kamiza *School of Public Health, College of Public Health, Taipei Medical University, 250 Wu-Hsing Street, Taipei, Taiwan.
Wen-Chang Wang *The Ph.D. Program for Translational Medicine, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan.
Jeng-Fu YouColorectal Section, Department of Surgery, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
Reiping TangColorectal Section, Department of Surgery, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
Huei-Tzu ChienDepartment of Nutrition and Health Sciences, Chang Gung University of Science and Technology, Taoyuan, Taiwan.
Chih-Hsiung LaiDepartment of Public Health, College of Medicine, Chang Gung University, Taoyuan, Taiwan.
Li-Ling ChiuDepartment of Nutrition and Health Sciences, Chang Gung University of Science and Technology, Taoyuan, Taiwan.
Tsai-Ping LoInstitute of Population Health Sciences, National Health Research Institutes, Miaoli, Taiwan.
Kuan-Yi HungInstitute of Population Health Sciences, National Health Research Institutes, Miaoli, Taiwan.
Chao A HsiungInstitute of Population Health Sciences, National Health Research Institutes, Miaoli, Taiwan.
Chih-Ching YehSchool of Public Health, College of Public Health, Taipei Medical University, 250 Wu-Hsing Street, Taipei, Taiwan. ccyeh@tmu.edu.tw.
National Health Research Institutes · TWChang Gung University · TWChang Gung University of Science and Technology · TWTaipei Medical University · TWChang Gung Memorial Hospital · TWChina Medical University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Patients with Lynch syndrome have a high risk of colorectal cancer (CRC). In this study, we estimated the age- and sex-specific cumulative risks of CRC in Han Chinese patients with Lynch syndrome caused by the pathogenic germline mutations in MLH1 or MSH2 in Taiwan. Based on 321 mutation carriers and 419 non-mutation carriers from 75 pedigrees collected in an Amsterdam criteria family registry in Taiwan, the age- and sex-specific cumulative risks of CRC in male carriers of mutation in MLH1 and MSH2 at the age of 70 years were 60.3% (95% confidence interval (CI) = 31.1%-89.9%) and 76.7% (95% CI = 37.2%-99.0%), respectively. For females, the cumulative risks of CRC at the age of 70 were estimated to be 30.6% (95% CI = 14.3%-57.7%) and 49.3% (95% CI = 21.9%-84.5%) in the carriers of MLH1 and MSH2 germline mutations, respectively. In conclusion, the cumulative risks of CRC at the age of 70 in the Han Chinese patients is higher in mutation carriers than non-mutation carriers and male mutation carriers have a higher cumulative risk of developing CRC than the female mutation carriers.

Indexed as

Germ-Line MutationAdultAgedAge FactorsAsian PeopleColorectal Neoplasms, Hereditary NonpolyposisFemaleHumansMaleMiddle AgedMutL ProteinsMutS Homolog 2 ProteinNeoplasm ProteinsRisk FactorsTaiwanMSH2 protein, humanMutL ProteinsMutS Homolog 2 ProteinNeoplasm ProteinsPMS1 protein, human

Identifiers

PMID33903664
PMCPMC8076276
OpenAlexW3157997765

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.