Evidence map›Paper›PMID 33903656›Full record

Trial reportScientific reports2021

The feasibility of the PAM intervention to support treatment-adherence in people with hypertension in primary care: a randomised clinical controlled trial.

Aikaterini Kassavou, Venus Mirzaei, Sonia Shpendi, James Brimicombe, Jagmohan Chauhan, Debi Bhattacharya, Felix Naughton, Wendy Hardeman, Helen Eborall, Miranda Van Emmenis and 11 more

Open access · goldAbstract readMulticenter StudyPragmatic Clinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 8 institutions in 1 country.

Aikaterini KassavouDepartment of Public Health and Primary Care, The Primary Care Unit, University of Cambridge, Cambridge, UK. kk532@medschl.cam.ac.uk.
Venus MirzaeiDepartment of Public Health and Primary Care, The Primary Care Unit, University of Cambridge, Cambridge, UK.
Sonia ShpendiDepartment of Public Health and Primary Care, The Primary Care Unit, University of Cambridge, Cambridge, UK.
James BrimicombeDepartment of Public Health and Primary Care, The Primary Care Unit, University of Cambridge, Cambridge, UK.
Jagmohan ChauhanDepartment of Computer Science and Technology, University of Cambridge, Cambridge, UK.
Debi BhattacharyaSchool of Pharmacy, University of East Anglia, Norwich, UK.
Felix NaughtonSchool of Health Sciences, University of East Anglia, Norwich, UK.
Wendy HardemanSchool of Health Sciences, University of East Anglia, Norwich, UK.
Helen EborallUsher Institute, University of Edinburgh, Edinburgh, UK.
Miranda Van EmmenisDepartment of Public Health and Primary Care, The Primary Care Unit, University of Cambridge, Cambridge, UK.
Anna De SimoniInstitute of Population Health Sciences, Queen Mary University of London, London, UK.
Amrit TakharCambridgeshire and Peterborough Clinical Commissioning Group, Cambridge, UK.
Pankaj GuptaDepartment of Metabolic Medicine and Chemical Pathology, University Hospitals of Leicester NHS Trust, Leicester, UK.
Prashanth PatelDepartment of Metabolic Medicine and Chemical Pathology, University Hospitals of Leicester NHS Trust, Leicester, UK.
Cecilia MascoloDepartment of Computer Science and Technology, University of Cambridge, Cambridge, UK.
Andrew Toby PrevostNightingale-Saunders Clinical Trials and Epidemiology Unit, King's College London, London, UK.
Stephen MorrisDepartment of Public Health and Primary Care, The Primary Care Unit, University of Cambridge, Cambridge, UK.
Simon GriffinDepartment of Public Health and Primary Care, The Primary Care Unit, University of Cambridge, Cambridge, UK.
Richard J McManusNuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.
Jonathan MantDepartment of Public Health and Primary Care, The Primary Care Unit, University of Cambridge, Cambridge, UK.
Stephen SuttonDepartment of Public Health and Primary Care, The Primary Care Unit, University of Cambridge, Cambridge, UK.
University of Cambridge · GBUniversity of East Anglia · GBUniversity Hospitals of Leicester NHS Trust · GBKing's College London · GBQueen Mary University of London · GBUniversity of Edinburgh · GBUniversity of Oxford · GBUniversity of Southampton · GB

Funding

Department of Health RP-PG-0615-20013Medical Research Council MC_UU_00006/6
6 · The paper itself

Abstract

The PAM intervention is a behavioural intervention to support adherence to anti-hypertensive medications and therefore to lower blood pressure. This feasibility trial recruited 101 nonadherent patients (54% male, mean age 65.8 years) with hypertension and high blood pressure from nine general practices in the UK. The trial had 15.5% uptake and 7.9% attrition rate. Patients were randomly allocated to two groups: the intervention group (n = 61) received the PAM intervention as an adjunct to usual care; the control group (n = 40) received usual care only. At 3 months, biochemically validated medication adherence was improved by 20% (95% CI 3-36%) in the intervention than control, and systolic blood pressure was reduced by 9.16 mmHg (95% CI 5.69-12.64) in intervention than control. Improvements in medication adherence and reductions in blood pressure suggested potential intervention effectiveness. For a subsample of patients, improvements in medication adherence and reductions in full lipid profile (cholesterol 1.39 mmol/mol 95% CI 0.64-1.40) and in glycated haemoglobin (3.08 mmol/mol, 95% CI 0.42-5.73) favoured the intervention. A larger trial will obtain rigorous evidence about the potential clinical effectiveness and cost-effectiveness of the intervention.Trial registration Trial date of first registration 28/01/2019. ISRCTN74504989. https://doi.org/10.1186/ISRCTN74504989 .

Indexed as

HypertensionMedication AdherencePrimary Health CareAgedFemaleGlycated HemoglobinHumansMaleMiddle AgedUnited KingdomGlycated Hemoglobin

Identifiers

PMID33903656
PMCPMC8076273
OpenAlexW3159133643

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.