Evidence map›Paper›PMID 33903634›Full record

Observational studyScientific reports2021

The pattern-recognition molecule H-ficolin in relation to diabetic kidney disease, mortality, and cardiovascular events in type 1 diabetes.

Jakob Appel Østergaard, Fanny Jansson Sigfrids, Carol Forsblom, Emma H Dahlström, Lena M Thorn, Valma Harjutsalo, Allan Flyvbjerg, Steffen Thiel, Troels Krarup Hansen, Per-Henrik Groop

Open access · goldAbstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 3 countries.

Jakob Appel Østergaard *Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark.
Fanny Jansson Sigfrids *Folkhälsan Institute of Genetics, Folkhälsan Research Center, Helsinki, Finland.
Carol ForsblomFolkhälsan Institute of Genetics, Folkhälsan Research Center, Helsinki, Finland.
Emma H DahlströmFolkhälsan Institute of Genetics, Folkhälsan Research Center, Helsinki, Finland.
Lena M ThornFolkhälsan Institute of Genetics, Folkhälsan Research Center, Helsinki, Finland.
Valma HarjutsaloFolkhälsan Institute of Genetics, Folkhälsan Research Center, Helsinki, Finland.
Allan FlyvbjergSteno Diabetes Center Copenhagen, The Capital Region of Denmark, Copenhagen, Denmark.
Steffen ThielDepartment of Biomedicine, Aarhus University, Aarhus, Denmark.
Troels Krarup HansenSteno Diabetes Center Aarhus, Aarhus University Hospital, Aarhus, Denmark.
Per-Henrik GroopFolkhälsan Institute of Genetics, Folkhälsan Research Center, Helsinki, Finland. per-henrik.groop@helsinki.fi.ORCID 0000-0003-4055-6954
University of Helsinki · FISteno Diabetes Centers · DKAarhus University · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

H-ficolin recognizes patterns on microorganisms and stressed cells and can activate the lectin pathway of the complement system. We aimed to assess H-ficolin in relation to the progression of diabetic kidney disease (DKD), all-cause mortality, diabetes-related mortality, and cardiovascular events. Event rates per 10-unit H-ficolin-increase were compared in an observational follow-up of 2,410 individuals with type 1 diabetes from the FinnDiane Study. DKD progression occurred in 400 individuals. The unadjusted hazard ratio (HR) for progression was 1.29 (1.18-1.40) and 1.16 (1.05-1.29) after adjustment for diabetes duration, sex, HbA

Indexed as

Cardiovascular DiseasesDiabetes Mellitus, Type 1Diabetic NephropathiesModels, CardiovascularAdultFemaleFinlandFollow-Up StudiesHumansLectinsMaleMiddle AgedFCN3 protein, humanLectins

Identifiers

PMID33903634
PMCPMC8076270
OpenAlexW3159038128

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.