Evidence map›Paper›PMID 33903621›Full record

ArticleScientific reports2021

Functional modulation of phosphodiesterase-6 by calcium in mouse rod photoreceptors.

Teemu Turunen, Ari Koskelainen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Structural basis of calmodulin modulation of the rod cyclic nucleotide-gated channel.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  3. Astrocytic Calcium and cAMP in Neurodegenerative Diseases.Frontiers in cellular neuroscience · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Teemu TurunenDepartment of Neuroscience and Biomedical Engineering, Aalto University School of Science, P.O. Box 12200, 00076, Aalto, Finland.
Ari KoskelainenDepartment of Neuroscience and Biomedical Engineering, Aalto University School of Science, P.O. Box 12200, 00076, Aalto, Finland. ari.koskelainen@aalto.fi.
Aalto University · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Phosphodiesterase-6 (PDE6) is a key protein in the G-protein cascade converting photon information to bioelectrical signals in vertebrate photoreceptor cells. Here, we demonstrate that PDE6 is regulated by calcium, contrary to the common view that PDE1 is the unique PDE class whose activity is modulated by intracellular Ca

Indexed as

Calcium SignalingAnimalsCalciumCyclic GMPCyclic Nucleotide Phosphodiesterases, Type 6FemaleGuanylate Cyclase-Activating ProteinsMaleMiceMice, KnockoutRetinal Rod Photoreceptor CellsCalciumCyclic GMPCyclic Nucleotide Phosphodiesterases, Type 6Guanylate Cyclase-Activating Proteins

Identifiers

PMID33903621
PMCPMC8076185
OpenAlexW3157901178

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.