ArticleNature communications2021
Single cell plasticity and population coding stability in auditory thalamus upon associative learning.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Rethinking hierarchy: the auditory system as an integrated cortical-subcortical network.Nature reviews. Neuroscience · 2026Review
- Tonotopic organization in the basal region of the ventromedial nucleus of the thalamus revealed by fiber photometry recording.Neurophotonics · 2026Article
- Neural Response Reliability as a Marker of the Transition of Neural Codes along Auditory Pathways.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Article
- Heterogeneous plasticity of amygdala interneurons in associative learning and extinction.Nature communications · 2025Article
- Learning-Associated Flexibility of Cortical Taste Coding Is Impaired in Shank3 Knockout Mice.bioRxiv : the preprint server for biology · 2025Article
- Early Life Stress Impairs VTA Coordination of BLA Network and Behavioral States.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Neural Correlates of Perceptual Plasticity in the Auditory Midbrain and Thalamus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Network state changes in sensory thalamus represent learned outcomes.Nature communications · 2024Article
- Amygdala and Cortex Relationships during Learning of a Sensory Discrimination Task.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Mixed Representations of Sound and Action in the Auditory Midbrain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Specific connectivity optimizes learning in thalamocortical loops.Cell reports · 2024Article
- Neural correlates of flexible sound perception in the auditory midbrain and thalamus.bioRxiv : the preprint server for biology · 2024Article
- Potentiation of cholinergic and corticofugal inputs to the lateral amygdala in threat learning.Cell reports · 2023Article
- Mixed representations of sound and action in the auditory midbrain.bioRxiv : the preprint server for biology · 2023Article
- From aversive associations to defensive programs: experience-dependent synaptic modifications in the central amygdala.Trends in neurosciences · 2023Review
- A PDMS-Agar Hybrid Microfluidic Device for the Investigation of Chemical-Mechanical Associative Learning Behavior ofMicromachines · 2023Article
- Article
- Expanding the canon: An inclusive neurobiology of thalamic and subthalamic fear circuits.Neuropharmacology · 2023Review
- Article
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cortical and limbic brain areas are regarded as centres for learning. However, how thalamic sensory relays participate in plasticity upon associative learning, yet support stable long-term sensory coding remains unknown. Using a miniature microscope imaging approach, we monitor the activity of populations of auditory thalamus (medial geniculate body) neurons in freely moving mice upon fear conditioning. We find that single cells exhibit mixed selectivity and heterogeneous plasticity patterns to auditory and aversive stimuli upon learning, which is conserved in amygdala-projecting medial geniculate body neurons. Activity in auditory thalamus to amygdala-projecting neurons stabilizes single cell plasticity in the total medial geniculate body population and is necessary for fear memory consolidation. In contrast to individual cells, population level encoding of auditory stimuli remained stable across days. Our data identifies auditory thalamus as a site for complex neuronal plasticity in fear learning upstream of the amygdala that is in an ideal position to drive plasticity in cortical and limbic brain areas. These findings suggest that medial geniculate body's role goes beyond a sole relay function by balancing experience-dependent, diverse single cell plasticity with consistent ensemble level representations of the sensory environment to support stable auditory perception with minimal affective bias.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.