Evidence map›Paper›PMID 33903242›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

An intracellular nanobody targeting T4SS effector inhibits

Wenqing Zhang, Mingqun Lin, Qi Yan, Khemraj Budachetri, Libo Hou, Ashweta Sahni, Hongyan Liu, Nien-Ching Han, Jeffrey Lakritz, Dehua Pei and 1 more

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 34 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Pharmacological Evaluation ofCurrent issues in molecular biology · 2025
    Article
  7. Review
  8. Experimental Approaches to Visualize Effector Protein Translocation During Host-Pathogen Interactions.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025
    Review
  9. Bismuth-Cyclized Cell-Penetrating Peptides.Molecular pharmaceutics · 2024
    Article
  10. Review
  11. Review
  12. International journal of molecular sciences · 2024
    Article
  13. RipE expression correlates with high ATP levels inFrontiers in cellular and infection microbiology · 2024
    Article
  14. Article
  15. Review
  16. Nanobodies: Robust miniprotein binders in biomedicine.Advanced drug delivery reviews · 2023
    Review
  17. Inhibition ofPNAS nexus · 2023
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Wenqing ZhangDepartment of Veterinary Biosciences, The Ohio State University, Columbus, OH 43210.
Mingqun LinDepartment of Veterinary Biosciences, The Ohio State University, Columbus, OH 43210.ORCID 0000-0002-9964-5460
Qi YanDepartment of Veterinary Biosciences, The Ohio State University, Columbus, OH 43210.ORCID 0000-0002-5963-9242
Khemraj BudachetriDepartment of Veterinary Biosciences, The Ohio State University, Columbus, OH 43210.ORCID 0000-0003-1254-792X
Libo HouDepartment of Veterinary Biosciences, The Ohio State University, Columbus, OH 43210.
Ashweta SahniDepartment of Chemistry and Biochemistry, The Ohio State University, Columbus, OH 43210.
Hongyan LiuDepartment of Veterinary Biosciences, The Ohio State University, Columbus, OH 43210.
Nien-Ching HanDepartment of Microbiology, The Ohio State University, Columbus, OH 43210.
Jeffrey LakritzDepartment of Veterinary Preventive Medicine, The Ohio State University, Columbus, OH 43210.ORCID 0000-0003-2143-0416
Dehua PeiDepartment of Chemistry and Biochemistry, The Ohio State University, Columbus, OH 43210.
Yasuko RikihisaDepartment of Veterinary Biosciences, The Ohio State University, Columbus, OH 43210; Rikihisa.1@osu.edu.ORCID 0000-0002-1870-5338
The Ohio State University · US

Funding

Inhibition of Ehrlichial Infection by Intracellular NanobodyR21AI146736 · NIAID · OHIO STATE UNIVERSITY · PI RIKIHISA, YASUKO · 2019 to 2020
$429k
NIAID NIH HHS R21 AI146736
6 · The paper itself

Abstract

Infection with obligatory intracellular bacteria is difficult to treat, as intracellular targets and delivery methods of therapeutics are not well known.

Indexed as

AnimalsApoptosisB-Lymphocyte SubsetsEhrlichia chaffeensisEhrlichiosisHost-Pathogen InteractionsHumansMiceReactive Oxygen SpeciesSingle-Domain AntibodiesType IV Secretion SystemsVirulence FactorsReactive Oxygen SpeciesSingle-Domain AntibodiesType IV Secretion SystemsVirulence Factorscell-permeable peptideEhrlichia chaffeensisEtf-1nanobodytype IV secretion system

Identifiers

PMID33903242
PMCPMC8106314
OpenAlexW3157685308

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.