Evidence map›Paper›PMID 33903223›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2021

Unique Actions of GABA Arising from Cytoplasmic Chloride Microdomains.

Negah Rahmati, Kieran P Normoyle, Joseph Glykys, Volodymyr I Dzhala, Kyle P Lillis, Kristopher T Kahle, Rehan Raiyyani, Theju Jacob, Kevin J Staley

Abstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. ClScience advances · 2024
    Article
  15. Optogenetic Determination of Dynamic and Cell-Type-Specific Inhibitory Reversal Potentials.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  16. Article
  17. Article
  18. Region and layer-specific expression of GABAFrontiers in cellular neuroscience · 2024
    Article
  19. Article
  20. Delaying the GABA Shift Indirectly Affects Membrane Properties in the Developing Hippocampus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Negah RahmatiDepartment of Neurology, Harvard Medical School and Massachusetts General Hospital, Boston, Massachusetts 02114.ORCID https://orcid.org/0000-0002-0709-5976
Kieran P NormoyleDepartment of Neurology, Harvard Medical School and Massachusetts General Hospital, Boston, Massachusetts 02114.
Joseph GlykysDepartment of Pediatrics and Neurology, Iowa Neuroscience Institute, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242.
Volodymyr I DzhalaDepartment of Neurology, Harvard Medical School and Massachusetts General Hospital, Boston, Massachusetts 02114.
Kyle P LillisDepartment of Neurology, Harvard Medical School and Massachusetts General Hospital, Boston, Massachusetts 02114.ORCID https://orcid.org/0000-0003-0219-8113
Kristopher T KahleDepartments of Neurosurgery, Pediatrics, and Cellular & Molecular Physiology, Yale School of Medicine, New Haven, Connecticut 06510.
Rehan RaiyyaniDepartment of Neurology, Harvard Medical School and Massachusetts General Hospital, Boston, Massachusetts 02114.
Theju JacobDepartment of Neurology, Harvard Medical School and Massachusetts General Hospital, Boston, Massachusetts 02114.
Kevin J StaleyDepartment of Neurology, Harvard Medical School and Massachusetts General Hospital, Boston, Massachusetts 02114 staley.kevin@mgh.harvard.edu.ORCID https://orcid.org/0000-0002-3072-518X

Funding

Neuronal Ion and Volume Shifts After Acute Brain InjuryR35NS116852 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI Kevin J. Staley · 2020 to 2026
$8.0M
Neuronal Chloride distribution by displacementR01NS040109 · NINDS · UNIVERSITY OF COLORADO DENVER · PI STALEY, KEVIN J. · 2000 to 2020
$7.2M
Water and chloride movement in neurons during seizure activityR01NS115800 · NINDS · UNIVERSITY OF IOWA · PI GLYKYS, JOSEPH C. · 2020 to 2024
$2.1M
Mechanisms of Interictal Spike GenerationR01NS112538 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI LILLIS, KYLE PATRICK · 2020 to 2024
$1.9M
Osmotic Therapy for Seizures in Pediatric Traumatic Brain InjuryK08NS091248 · NINDS · UNIVERSITY OF IOWA · PI GLYKYS, JOSEPH C. · 2015 to 2019
$978k
NINDS NIH HHS K08 NS091248NINDS NIH HHS R01 NS040109NINDS NIH HHS R01 NS112538NINDS NIH HHS R01 NS115800NINDS NIH HHS R35 NS116852
6 · The paper itself

Abstract

Developmental, cellular, and subcellular variations in the direction of neuronal Cl

Indexed as

AnimalsChloridesCytoplasmgamma-Aminobutyric AcidMiceNeuronsSynaptic TransmissionChloridesgamma-Aminobutyric Acidchloridechloride microdomainsFLIMGABAGABAA receptorsSuperClomeleon

Identifiers

PMID33903223
PMCPMC8197632

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.