Evidence map›Paper›PMID 33903074›Full record

ArticleInfection, disease & health2021

SARS-CoV-2 seroprevalence in healthcare workers in a tertiary healthcare network in Victoria, Australia.

Jillian Sy Lau, Paul Buntine, Melanie Price, Peteris Darzins, Evan Newnham, Ailie Connell, Roy Chean, Glenn Edwards, Stephen Guy

Abstract read
In one paragraph

Article in Infection, disease & health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jillian Sy LauDepartment of Infectious Diseases, Eastern Health, Box Hill, 3128, Australia. Electronic address: jillian.lau@monash.edu.
Paul BuntineDepartment of Emergency Medicine, Eastern Health, Box Hill, 3128, Australia; Eastern Health Clinical School, Monash University, Clayton, 3800, Australia.
Melanie PriceDepartment of Emergency Medicine, Eastern Health, Box Hill, 3128, Australia.
Peteris DarzinsEastern Health Clinical School, Monash University, Clayton, 3800, Australia.
Evan NewnhamEastern Health Clinical School, Monash University, Clayton, 3800, Australia.
Ailie ConnellEastern Health Pathology, Eastern Health, Box Hill, 3128, Australia.
Roy CheanEastern Health Pathology, Eastern Health, Box Hill, 3128, Australia.
Glenn EdwardsEastern Health Pathology, Eastern Health, Box Hill, 3128, Australia.
Stephen GuyDepartment of Infectious Diseases, Eastern Health, Box Hill, 3128, Australia; Eastern Health Clinical School, Monash University, Clayton, 3800, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHealthcare workers (HCW) are exposed to an increased risk of COVID-19 through direct contact with patients and patient environments. We calculated the; seroprevalence of SARS-CoV-2 in HCW at Eastern Health, a tertiary healthcare network in Victoria, and assessed associations with demographics, work location and role.

methodsA cross-sectional cohort study of HCW at Eastern Health was conducted. Serum was analysed for the presence of antibodies to SARS-CoV-2, and all participants completed; an online survey collecting information on demographics, place of work, role, and exposures; to COVID-19. Seroprevalence was calculated as the proportion participants with SARS-CoV-2; antibodies out of all tested individuals.

resultsThe crude seroprevalence of SARS-CoV-2 antibodies in this study was 2.17% (16/736). Thirteen of the 16 (81.2%) positive cases had previously been diagnosed with COVID-19 by PCR: the seroprevalence in the group not previously diagnosed with COVID by PCR was 0.42% (3/720). Having direct contact with COVID-19 patients did not increase the likelihood of having positive serology. A prior history of symptoms consistent with COVID-19 was associated with a higher likelihood of having positive serology (OR 17.2, p = 0.006, 95%CI: 2.25-131.55).

conclusionOur calculated seroprevalence of 2.17% is higher than estimated in the general Australian population, but lower than that reported in HCW internationally. The; majority of those with positive serology in our study had previously been diagnosed with COVID-19 by PCR based testing. Seropositivity was not associated with interaction with COVID-19 positive patients, highlighting effective infection prevention and control practices within the workplace.

Indexed as

AdultAgedAntibodies, ViralCohort StudiesCOVID-19Cross-Sectional StudiesFemaleHealth PersonnelHumansMaleMiddle AgedSARS-CoV-2Seroepidemiologic StudiesTertiary Health CareVictoriaYoung AdultAntibodies, ViralCOVID-19Healthcare workerSARS-CoV-2Seroprevalence

Identifiers

PMID33903074
PMCPMC8043617

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.