ArticleJournal of medical case reports2021
Sirenomelia: two case reports.
Article in Journal of medical case reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 22 citations in OpenAlex.
- Prenatal ultrasound diagnosis of sirenomelia: A case report.Radiology case reports · 2026Article
- Whole-genome resequencing with multidimensional annotation revealed pathogenic networks in sirenomelia.Italian journal of pediatrics · 2026Article
- Article
- Sirenomelia and the Spectrum of Caudal Anomalies: Clinical Reflections From a Preterm Termination.Clinical case reports · 2025Article
- [Sirenomelia: a case report].Revista medica del Instituto Mexicano del Seguro Social · 2024Article
- Article
- Sirenomelia: An anatomical assessment and genetic sex determination of two cases.Journal of anatomy · 2024Article
- Caudal Regression Syndrome First Diagnosed in Adulthood: A Case Report and a Review of the Literature.Diagnostics (Basel, Switzerland) · 2024Article
- Defective blastogenesis of postnatally diagnosed type VI sirenomelia in a young primigravida: A case report.SAGE open medical case reports · 2024Article
- Surgical Management of Sirenomelia: A Case Study.Plastic and reconstructive surgery. Global open · 2023Article
- Antenatal diagnosis of sympus dipus by MRI.European journal of obstetrics & gynecology and reproductive biology: X · 2023Article
- Caudal Regression Syndrome-A Narrative Review: An Orthopedic Point of View.Children (Basel, Switzerland) · 2023Review
- Article
- What is your diagnosis?Journal of the Turkish German Gynecological Association · 2022Article
- Sirenomelia: A case report.SAGE open medical case reports · 2022Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSirenomelia, also called mermaid syndrome, is a rare lethal multi-system congenital deformity with an incidence of one in 60,000-70,000 pregnancies. Sirenomelia is mainly characterized by the fusion of lower limbs and is widely associated with severe urogenital and gastrointestinal malformations. The presence of a single umbilical artery derived from the vitelline artery is the main anatomical feature distinguishing sirenomelia from caudal regression syndrome. First-trimester diagnosis of this disorder and induced abortion may be the safest medical option. In this report, two cases of sirenomelia that occurred in an white family will be discussed. CASE PRESENTATION: We report two white cases of sirenomelia occurring in a 31-year-old multigravid pregnant woman. In the first pregnancy (18 weeks of gestation) abortion was performed, but in the third pregnancy (32 weeks) the stillborn baby was delivered by spontaneous vaginal birth. In the second and fourth pregnancies, however, she gave birth to normal babies. Three-dimensional ultrasound imaging showed fusion of the lower limbs. Neither she nor any member of her family had a history of diabetes. In terms of other risk factors, she had no history of exposure to teratogenic agents during her pregnancy. Also, her marriage was non-consanguineous.
conclusionThis report suggests the existence of a genetic background in this mother with a Mendelian inheritance pattern of 50% second-generation incidence in her offspring.
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