Evidence map›Paper›PMID 33902667›Full record

Trial reportScandinavian journal of trauma, resuscitation and emergency medicine2021

Point-of-care ultrasound of the heart and lungs in patients with respiratory failure: a pragmatic randomized controlled multicenter trial.

M Riishede, A T Lassen, G Baatrup, P I Pietersen, N Jacobsen, K N Jeschke, C B Laursen

2 registry-linked trialsOpen access · goldAbstract readMulticenter StudyPragmatic Clinical TrialRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Scandinavian journal of trauma, resuscitation and emergency medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02550184 naunknown statusnot on this map

Ultrasonography in the Emergency Department. A Randomised Controlled Multicenter Study.

TypeinterventionalSponsorOdense University HospitalRan2015 to 2016Enrolled288ConditionsAcute Respiratory Failure, Chest PainArmsFocused ultrasonographic examination.
NCT06529315 nacompletednot on this mapstarted 2024, after this paper: background citation

Effects of Point-of-Care Ultrasound in Multidisciplinary Medical Wards

TypeinterventionalSponsorNational Taiwan University HospitalRan2024 to 2024Enrolled144ConditionsPoint-of-care UltrasoundArmsPoint-of-Care Ultrasound
3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Article
  7. Observational
  8. Article
  9. Review
  10. Article
  11. Observational
  12. Review
  13. PrehospitaL Ultrasound in Undifferentiated DyspnEa (PreLUDE): a prospective, clinical, observational study.Scandinavian journal of trauma, resuscitation and emergency medicine · 2023
    Observational
  14. Review
  15. Cardiac POCUS: Another Tool in the Armory.Kansas journal of medicine · 2023
    Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

M RiishedeDepartment of Surgery, Odense University Hospital, 5700, Svendborg, Denmark. Minna.Riishede@rsyd.dk.ORCID http://orcid.org/0000-0002-5785-3317
A T LassenDepartment of Clinical Research, University of Southern Denmark, SDU-Odense, 5000, Odense, Denmark.
G BaatrupDepartment of Surgery, Odense University Hospital, 5700, Svendborg, Denmark.
P I PietersenDepartment of Clinical Research, University of Southern Denmark, SDU-Odense, 5000, Odense, Denmark.
N JacobsenDepartment of Clinical Research, University of Southern Denmark, SDU-Odense, 5000, Odense, Denmark.
K N JeschkeDepartment of Respiratory Medicine, Copenhagen University Hospital, 2650, Hvidovre, Denmark.
C B LaursenDepartment of Clinical Research, University of Southern Denmark, SDU-Odense, 5000, Odense, Denmark.
University of Southern Denmark · DKCopenhagen University Hospital · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPoint-of-care ultrasound is a focus oriented tool for differentiating among cardiopulmonary diseases. Its value in the hands of emergency physicians, with various ultrasound experience, remains uncertain. We tested the hypothesis that, in emergency department patients with signs of respiratory failure, a point-of-care cardiopulmonary ultrasound along with standard clinical examination, performed by emergency physicians with various ultrasound experience would increase the proportion of patients with presumptive diagnoses in agreement with final diagnoses at four hours after admission compared to standard clinical examination alone.

methodsIn this prospective multicenter superiority trial in Danish emergency departments we randomly assigned patients presenting with acute signs of respiratory failure to intervention or control in a 1:1 ratio by block randomization. Patients received point-of-care cardiopulmonary ultrasound examination within four hours from admission. Ultrasound results were unblinded for the treating emergency physician in the intervention group. Final diagnoses and treatment were determined by blinded review of the medical record after the patients´ discharge.

resultsFrom October 9, 2015 to April 5, 2017, we randomized 218 patients and included 211 in the final analyses. At four hours we found; no change in the proportion of patients with presumptive diagnoses in agreement with final diagnoses; intervention 79·25% (95% CI 70·3-86·0), control 77·1% (95% CI 68·0-84·3), an increased proportion of appropriate treatment prescribed; intervention 79·3% (95% CI 70·3-86·0), control 65·7% (95% CI 56·0-74·3) and of patients who spent less than 1 day in hospital; intervention n = 42 (39·6%, 25·8 38·4), control n = 25 (23·8%, 16·5-33·0). No adverse events were reported.

conclusionsFocused cardiopulmonary ultrasound added to standard clinical examination in patients with signs of respiratory failure had no impact on the diagnostic accuracy, but significantly increased the proportion of appropriate treatment prescribed and the proportion of patients who spent less than 1 day in hospital.

trial registrationhttps://clinicaltrials.gov/ , number NCT02550184 .

Indexed as

Emergency Service, HospitalPoint-of-Care SystemsAgedFemaleHospitalizationHumansLungMaleMiddle AgedProspective StudiesRespiratory InsufficiencyUltrasonographyDiagnostic accuracyEmergency departmentHigh acuityPoint–of-care ultrasoundRespiratory diseaseUltrasound

Identifiers

PMID33902667
PMCPMC8073910
OpenAlexW3159027756

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.