Evidence map›Paper›PMID 33902640›Full record

ArticleJournal of translational medicine2021

Automatic identification of myopic maculopathy related imaging features in optic disc region via machine learning methods.

Yuchen Du, Qiuying Chen, Ying Fan, Jianfeng Zhu, Jiangnan He, Haidong Zou, Dazhen Sun, Bowen Xin, David Feng, Michael Fulham and 3 more

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in Journal of translational medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 15 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 6 pooled it
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 6 syntheses or guidelines pooled it, 21 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Yuchen Du *The Institute of Image Processing and Pattern Recognition, Department of Automation, Shanghai Jiao Tong University (SJTU), 800 Dongchuan RD. Minhang District, Shanghai, 200240, People's Republic of China.
Qiuying Chen *Department of Preventative Ophthalmology, Shanghai Eye Diseases Prevention and Treatment Center, Shanghai Eye Hospital, No. 380 Kangding Road, Shanghai, 200040, China.
Ying Fan *Department of Preventative Ophthalmology, Shanghai Eye Diseases Prevention and Treatment Center, Shanghai Eye Hospital, No. 380 Kangding Road, Shanghai, 200040, China.
Jianfeng ZhuDepartment of Preventative Ophthalmology, Shanghai Eye Diseases Prevention and Treatment Center, Shanghai Eye Hospital, No. 380 Kangding Road, Shanghai, 200040, China.
Jiangnan HeDepartment of Preventative Ophthalmology, Shanghai Eye Diseases Prevention and Treatment Center, Shanghai Eye Hospital, No. 380 Kangding Road, Shanghai, 200040, China.
Haidong ZouDepartment of Preventative Ophthalmology, Shanghai Eye Diseases Prevention and Treatment Center, Shanghai Eye Hospital, No. 380 Kangding Road, Shanghai, 200040, China.
Dazhen SunThe Institute of Image Processing and Pattern Recognition, Department of Automation, Shanghai Jiao Tong University (SJTU), 800 Dongchuan RD. Minhang District, Shanghai, 200240, People's Republic of China.
Bowen XinBiomedical and Multimedia Information Technology Research Group, School of Computer Science, The University of Sydney, Sydney, NSW, 2006, Australia.
David FengBiomedical and Multimedia Information Technology Research Group, School of Computer Science, The University of Sydney, Sydney, NSW, 2006, Australia.
Michael FulhamDepartment of Molecular Imaging, Royal Prince Alfred Hospital and the University of Sydney, Sydney, Australia.
Xiuying WangBiomedical and Multimedia Information Technology Research Group, School of Computer Science, The University of Sydney, Sydney, NSW, 2006, Australia.
Lisheng WangThe Institute of Image Processing and Pattern Recognition, Department of Automation, Shanghai Jiao Tong University (SJTU), 800 Dongchuan RD. Minhang District, Shanghai, 200240, People's Republic of China. lswang@sjtu.edu.cn.
Xun XuDepartment of Preventative Ophthalmology, Shanghai Eye Diseases Prevention and Treatment Center, Shanghai Eye Hospital, No. 380 Kangding Road, Shanghai, 200040, China. drxuxun@sjtu.edu.cn.ORCID http://orcid.org/0000-0002-4246-4343
Shanghai Eye Disease Prevention & Treatment Center · CNThe University of Sydney · AUShanghai Jiao Tong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMyopic maculopathy (MM) is the most serious and irreversible complication of pathologic myopia, which is a major cause of visual impairment and blindness. Clinic proposed limited number of factors related to MM. To explore additional features strongly related with MM from optic disc region, we employ a machine learning based radiomics analysis method, which could explore and quantify more hidden or imperceptible MM-related features to the naked eyes and contribute to a more comprehensive understanding of MM and therefore may assist to distinguish the high-risk population in an early stage.

methodsA total of 457 eyes (313 patients) were enrolled and were divided into severe MM group and without severe MM group. Radiomics analysis was applied to depict features significantly correlated with severe MM from optic disc region. Receiver Operating Characteristic were used to evaluate these features' performance of classifying severe MM.

resultsEight new MM-related image features were discovered from the optic disc region, which described the shapes, textural patterns and intensity distributions of optic disc region. Compared with clinically reported MM-related features, these newly discovered features exhibited better abilities on severe MM classification. And the mean values of most features were markedly changed between patients with peripapillary diffuse chorioretinal atrophy (PDCA) and macular diffuse chorioretinal atrophy (MDCA).

conclusionsMachine learning and radiomics method are useful tools for mining more MM-related features from the optic disc region, by which complex or even hidden MM-related features can be discovered and decoded. In this paper, eight new MM-related image features were found, which would be useful for further quantitative study of MM-progression. As a nontrivial byproduct, marked changes between PDCA and MDCA was discovered by both new image features and clinic features.

Indexed as

Macular DegenerationMyopia, DegenerativeOptic DiskRetinal DiseasesHumansMachine LearningFeature miningMachine learningMyopic maculopathyPathologic myopiaRadiomics

Identifiers

PMID33902640
PMCPMC8074495
OpenAlexW3157553398

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.