ArticleBehavioral and brain functions : BBF2021
Linalool odor-induced analgesia is triggered by TRPA1-independent pathway in mice.
Article in Behavioral and brain functions : BBF, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 18 citations in OpenAlex.
- Pharmacological and molecular insights into linalool-richVeterinary world · 2025Article
- The anti-nociceptive and anti-inflammatory effects of Pelargonium graveolens essential oil nanoemulsion in mice.Scientific reports · 2025Article
- Linalool as a potential agent for inhibiting Escherichia coli biofilm formation and exopolysaccharide production.BMC veterinary research · 2025Article
- Dual role of transient receptor potential ankyrin 1 in respiratory and gastrointestinal physiology: From molecular mechanisms to therapeutic targets.Frontiers in physiology · 2024Review
- Inhibitory effects of linalool, an essential oil component ofBiochemistry and biophysics reports · 2023Article
- Review
- Growth-phase specific regulation of cviI/R based quorum sensing associated virulence factors in Chromobacterium violaceum by linalool, a monoterpenoid.World journal of microbiology & biotechnology · 2022Article
- TRP channels and monoterpenes: Past and current leads on analgesic properties.Frontiers in molecular neuroscience · 2022Review
- Possible Use of Phytochemicals for Recovery from COVID-19-Induced Anosmia and Ageusia.International journal of molecular sciences · 2021Review
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
We had recently reported that linalool odor exposure induced significant analgesic effects in mice and that the effects were disappeared in olfactory-deprived mice in which the olfactory epithelium was damaged, thus indicating that the effects were triggered by chemical senses evoked by linalool odor exposure. However, the peripheral neuronal mechanisms, including linalool receptors that contribute toward triggering the linalool odor-induced analgesia, still remain unexplored. In vitro studies have shown that the transient receptor potential ankyrin 1 (TRPA1) responded to linalool, thus raising the possibility that TRPA1 expressed on the trigeminal nerve terminal detects linalool odor inhaled into the nostril and triggers the analgesic effects. To address this hypothesis, we measured the behavioral pain threshold for noxious mechanical stimulation in TRPA1-deficient mice. In contrast to our expectation, we found a significant increase in the threshold after linalool odor exposure in TRPA1-deficient mice, indicating the analgesic effects of linalool odor even in TRPA1-deficient mice. Furthermore, intranasal application of TRPA1 selective antagonist did not alter the analgesic effect of linalool odor. These results showed that the linalool odor-induced analgesia was triggered by a TRPA1-independent pathway in mice.
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