Observational studyJournal of translational medicine2021
Phase angle and Mediterranean diet in patients with acne: Two easy tools for assessing the clinical severity of disease.
Observational study in Journal of translational medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 37 citations in OpenAlex.
- Unsaturated Fatty Acids and the Risk of Acne: A Mendelian Randomization Study the Impact of Unsaturated Fatty Acids on Acne.Clinical, cosmetic and investigational dermatology · 2026Article
- The mediterranean diet and acne vulgaris: a systematic review and meta-analysis.Nutrition & metabolism · 2025Review
- Mediterranean Diet Adherence and Acne Vulgaris Severity in an Iranian Population: A Case-Control Study.Health science reports · 2025Article
- Integration of high-frequency ultrasound with the Global Acne Grading System for prediction of treatment efficiency in acne vulgaris.Ultrasonography (Seoul, Korea) · 2025Article
- Review
- Plant-Based Foods for Chronic Skin Diseases: A Focus on the Mediterranean Diet.Current nutrition reports · 2025Review
- Lifestyle, medication use, and age considerations with acne vulgaris: A prospective study.JEADV clinical practice · 2025Article
- Association of lifestyle, physiological factors, and body composition with the facial skin microbiota in acne vulgaris.Frontiers in medicine · 2025Article
- Nutritional and Microbial Strategies for Treating Acne, Alopecia, and Atopic Dermatitis.Nutrients · 2024Review
- Do patients with acne tend to have increased body fat? Comparison of body composition analysis of patients with acne vulgaris and healthy individuals: a prospective case control study.Archives of dermatological research · 2024Article
- The Antioxidant Power of a Diet May Improve the Quality of Life of Young Women with Acne Vulgaris.Nutrients · 2024Article
- Very low-calorie ketogenic diet (VLCKD): a therapeutic nutritional tool for acne?Journal of translational medicine · 2024Article
- Acne Vulgaris and adherence to the mediterranean diet among university students: a case‒control study.Journal of health, population, and nutrition · 2024Article
- Very low-calorie ketogenic diet (VLCKD): an antihypertensive nutritional approach.Journal of translational medicine · 2023Article
- Associations of adherence to Mediterranean-like diet pattern with incident rosacea: A prospective cohort study of government employees in China.Frontiers in nutrition · 2023Article
- Gut Microbiota in Psoriasis.Nutrients · 2022Review
- The influence of Mediterranean diet in acne pathogenesis and the correlation with insulin-like growth factor-1 serum levels: Implications and results.Dermatology reports · 2022Article
- Article
- Association of Trimethylamine N-Oxide (TMAO) with the Clinical Severity of Hidradenitis Suppurativa (Acne Inversa).Nutrients · 2021Observational
- Lipid Profile Scores Predict Severity of Pemphigus: A Cross-Sectional Study.Indian journal of dermatologyArticle
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAcne is a chronic, inflammatory and debilitating skin disorder. Dietary factors and nutritional status are among the exacerbating factors of acne. Phase angle (PhA), a direct measure of Bioelectrical Impedance Analysis (BIA), represents an indicator of the chronic inflammatory state. The Mediterranean diet (MD) is a healthy dietary pattern that can exert anti-inflammatory effects in several inflammatory diseases. We aimed to investigate the difference in PhA and adherence to the MD and their associations with the severity of acne in a sample of naïve treatment patients with acne compared to control group. MATERIALS: In this cross-sectional, case-control, observational study, we enrolled 51 patients with acne and 51 control individuals. Body composition was evaluated by a BIA phase-sensitive system (50 kHz BIA 101 RJL, Akern Bioresearch, Florence, Italy, Akern). For adherence to the MD, we have used the PREvención con DIeta MEDiterránea (PREDIMED) questionnaire. The clinical severity of acne was assessed by using the global acne grading system (GAGS), a quantitative scoring system to assess acne severity.
resultsPatients with acne had a worse body composition, in particular smaller PhA (p = 0.003), and a lower adherence to the MD (p < 0.001) than the control group, in spite of no differences in gender, age and BMI between the two groups. Stratifying patients with acne according to GAGS categories, both PhA (p = 0.006) and PREDIMED score (p = 0.007) decreased significantly in severe acne than mild/moderate acne. The GAGS score was negative correlations with PhA (r = - 0.478, p < 0.001) and PREDIMED score (r = - 0.504, p < 0.001). The results of the multivariate analysis showed PhA and PREDIMED score were the major determinants of GAGS score (p < 0.001). The receiver operator characteristic (ROC) analysis reporting a value of PhA of ≤ 6.1° and a PREDIMED score of ≤ 9 identified patients with acne with the highest clinical severity of the disease.
conclusionsNovel correlations were reported between PhA and the degree of adherence to the MD with acne severity. Of interest, PhA and PREDIMED scores might represent possible markers of the severity of acne in a clinical setting. This study highlights how a cooperation between dermatologist and nutritionists might provide a combination key in the complex management of acne patients.
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