Evidence map›Paper›PMID 33902478›Full record

ArticleBMC nephrology2021

Kidney age - chronological age difference (KCD) score provides an age-adapted measure of kidney function.

Duncan J Campbell, Jennifer M Coller, Fei Fei Gong, Michele McGrady, Umberto Boffa, Louise Shiel, Danny Liew, Simon Stewart, Alice J Owen, Henry Krum and 2 more

3 registry-linked trialsOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC nephrology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00400257 completednot on this map

SCREEN-HF (Screening Evaluation of the Evolution of New Heart Failure)

TypeobservationalSponsorIngrid HopperRan2007 to 2015Enrolled3,500ConditionsHeart FailureArmsEarly detection of heart failure
NCT00604006 phase3completednot on this map

SCREEN-HFI (SCReening Evaluation of the Evolution of New Heart Failure Intervention Study)

TypeinterventionalSponsorMonash UniversityRan2008 to 2015Enrolled20ConditionsHeart FailureArmsSpironolactone, Placebo
NCT01581827 completednot on this map

SCREEN-HFL (SCReening Evaluation of the Evolution of New Heart Failure) - a Longitudinal Study

TypeobservationalSponsorMonash UniversityRan2009 to 2017Enrolled3,000ConditionsHeart Failure
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 1 country.

Duncan J CampbellSt. Vincent's Institute of Medical Research, 41 Victoria Parade, Fitzroy, Victoria, 3065, Australia. dcampbell@svi.edu.au.
Jennifer M CollerSt. Vincent's Hospital, Melbourne, Victoria, Australia.
Fei Fei GongSt. Vincent's Institute of Medical Research, 41 Victoria Parade, Fitzroy, Victoria, 3065, Australia.
Michele McGradyRoyal Prince Alfred Hospital, Sydney, New South Wales, Australia.
Umberto BoffaSchool of Medicine, University of Adelaide, Adelaide, South Australia, Australia.
Louise ShielPublic Health and Preventive Medicine, Monash University, Prahran, Victoria, Australia.
Danny LiewPublic Health and Preventive Medicine, Monash University, Prahran, Victoria, Australia.
Simon StewartTorrens University Australia, Adelaide, South Australia, Australia.
Alice J OwenPublic Health and Preventive Medicine, Monash University, Prahran, Victoria, Australia.
Henry KrumPublic Health and Preventive Medicine, Monash University, Prahran, Victoria, Australia.
Christopher M ReidPublic Health and Preventive Medicine, Monash University, Prahran, Victoria, Australia.
David L PriorUniversity of Melbourne, Parkville, Victoria, Australia.
Monash University · AUSt Vincent's Hospital · AUSt Vincents Institute of Medical Research · AURoyal Prince Alfred Hospital · AUTorrens University Australia · AUUniversity of Adelaide · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGiven the age-related decline in glomerular filtration rate (GFR) in healthy individuals, we examined the association of all-cause death or cardiovascular event with the Kidney age - Chronological age Difference (KCD) score, whereby an individual's kidney age is estimated from their estimated GFR (eGFR) and the age-dependent eGFR decline reported for healthy living potential kidney donors.

methodsWe examined the association between death or cardiovascular event and KCD score, age-dependent stepped eGFR criteria (eGFRstep), and eGFR < 60 ml/min/1.73 m

resultsIn proportional hazards analysis, KCD score ≥ 20 years (KCD20) was associated with increased risk of death or cardiovascular event in unadjusted analysis and after adjustment for age, sex and cardiovascular risk factors. Addition of KCD20, eGFRstep or eGFR60 to a cardiovascular risk factor model did not improve area under the curve for identification of individuals who experienced death or cardiovascular event in receiver operating characteristic curve analysis. However, addition of KCD20 or eGFR60, but not eGFRstep, to a cardiovascular risk factor model improved net reclassification and integrated discrimination. KCD20 identified individuals who experienced death or cardiovascular event with greater sensitivity than eGFRstep for all participants, and with greater sensitivity than eGFR60 for participants aged 60-69 years, with similar sensitivities for men and women.

conclusionsIn this high cardiovascular risk cohort aged ≥60 years, the KCD score provided an age-adapted measure of kidney function that may assist patient education, and KCD20 provided an age-adapted criterion of eGFR-related increased risk of death or cardiovascular event. Further studies that include the full age spectrum are required to examine the optimal KCD score cut point that identifies increased risk of death or cardiovascular event, and kidney events, associated with impaired kidney function, and whether the optimal KCD score cut point is similar for men and women.

trial registrationClinicalTrials.gov NCT00400257 , NCT00604006 , and NCT01581827 .

Indexed as

Cause of DeathGlomerular Filtration RateAgedAgingCardiovascular DiseasesFemaleHumansKidneyMaleMiddle AgedRenal Insufficiency, ChronicRisk FactorsSex FactorsTissue DonorsAll-cause mortalityCardiovascular diseaseChronic kidney diseaseeGFR

Identifiers

PMID33902478
PMCPMC8077774
OpenAlexW3157547099

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.