Evidence map›Paper›PMID 33901788›Full record

ArticleRespiratory medicine2021

Evolution of lung function and chest CT 6 months after COVID-19 pneumonia: Real-life data from a Belgian University Hospital.

Dimitri Stylemans, Jelle Smet, Shane Hanon, Daniël Schuermans, Bart Ilsen, Jef Vandemeulebroucke, Eef Vanderhelst, Sylvia Verbanck

Open access · bronzeAbstract read
In one paragraph

Article in Respiratory medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 2 pooled it
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 33 citations in OpenAlex.

  1. Post-COVID-19 dyspnoea and pulmonary imaging: a systematic review and meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2023
    Pooled it
  2. ESCMID rapid guidelines for assessment and management of long COVID.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2022
    Guideline
  3. Observational
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  10. Post-COVID Pulmonary Function Test Evaluation.Turkish thoracic journal · 2022
    Article
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  13. Long-Term Characteristics of Severe COVID-19: Respiratory Function, Functional Capacity, and Quality of Life.International journal of environmental research and public health · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Dimitri StylemansVrije Universiteit Brussel, University Hospital UZ Brussel, Respiratory Division, Laarbeeklaan 101, 1090 Brussels, Belgium. Electronic address: dimitri.stylemans@uzbrussel.be.
Jelle SmetVrije Universiteit Brussel, University Hospital UZ Brussel, Respiratory Division, Laarbeeklaan 101, 1090 Brussels, Belgium.
Shane HanonVrije Universiteit Brussel, University Hospital UZ Brussel, Respiratory Division, Laarbeeklaan 101, 1090 Brussels, Belgium.
Daniël SchuermansVrije Universiteit Brussel, University Hospital UZ Brussel, Respiratory Division, Laarbeeklaan 101, 1090 Brussels, Belgium.
Bart IlsenVrije Universiteit Brussel, University Hospital UZ Brussel, Radiology Division, Laarbeeklaan 101, 1090 Brussels, Belgium.
Jef VandemeulebrouckeVrije Universiteit Brussel (VUB), Department of Electronics and Informatics (ETRO), Pleinlaan 2, 1050 Brussels, Belgium.
Eef VanderhelstVrije Universiteit Brussel, University Hospital UZ Brussel, Respiratory Division, Laarbeeklaan 101, 1090 Brussels, Belgium.
Sylvia VerbanckVrije Universiteit Brussel, University Hospital UZ Brussel, Respiratory Division, Laarbeeklaan 101, 1090 Brussels, Belgium.
Vrije Universiteit Brussel · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionMost post COVID-19 follow-up studies are limited to a follow-up of 3 months. Whether a favorable evolution in lung function and/or radiological abnormalities is to be expected beyond 3 months is uncertain. MATERIALS AND

methodsWe conducted a real-life follow-up study assessing the evolution in lung function, chest CT and ventilation distribution between 10 weeks and 6 months after diagnosis of COVID-19 pneumonia.

resultsSeventy-nine patients were assessed at 6 months of whom 63 had chest CT at both follow-up visits and 46 had multiple breath washout testing to obtain lung clearance index (LCI). The study group was divided into a restrictive (n = 39) and a non-restrictive subgroup (n = 40) based on TLC z-score. Restriction was associated with a history of intubation, neuromuscular blockade use and critical illness polyneuropathy. Restriction significantly improved over time, but was not resolved by 6 months (median TLC z-score of -2.2 [IQR: -2.7; -1.5] at 6 months versus -2.7 [IQR: -3.1; -2.1] at 10 weeks). LCI did not evolve between both follow-up visits. Symptoms and chest CT score improved irrespective of restriction.

conclusionWe observed a disconnect between the improvement of COVID-19 related symptoms, chest CT lesions, and corresponding lung function. While CT imaging is almost normalized at 6 months, a further reduction of pulmonary restriction may be hoped for beyond 6 months in those patients showing restriction at their first follow-up visit.

Indexed as

Respiratory Physiological PhenomenaBelgiumCOVID-19FemaleFollow-Up StudiesHumansLungMaleMiddle AgedPandemicsRespiratory Function TestsRetrospective StudiesTomography, X-Ray ComputedChest CTLCIPost COVID-19Pulmonary function testing

Identifiers

PMID33901788
PMCPMC8053365
OpenAlexW3153972543

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.